Olmesartan/amlodipine/hydrochlorothiazide 

Tribenzor 

Tribenzor is a comprehensive blood pressure management medication that combines three active ingredients—olmesartan, amlodipine, and hydrochlorothiazide. This potent trio works together to effectively lower high blood pressure, mitigating the risk of heart attack, stroke, and kidney failure. Olmesartan acts as an angiotensin II receptor blocker to dilate blood vessels, amlodipine is a calcium channel blocker that relaxes the heart and blood vessels, and hydrochlorothiazide is a diuretic that reduces fluid overload. Available in various dosages, Tribenzor allows for flexible treatment plans tailored to individual patient needs, enhancing therapeutic efficacy and safety. Patients need to take Tribenzor consistently, monitor their blood pressure regularly, and undergo periodic health checks to manage side effects & adjust dosages as necessary. However, Tribenzor is not suitable during pregnancy and for those with severe renal impairment or allergies to its components. Always consult a healthcare expert prior to starting or adjusting Tribenzor treatment.

Product Overview

Tribenzor is a multifaceted antihypertensive treatment that combines three powerful medications—olmesartan, amlodipine, and hydrochlorothiazide—to manage high blood pressure effectively. This combination targets various mechanisms of blood pressure regulation: olmesartan blocks the action of angiotensin II, a potent vasoconstrictor; amlodipine relaxes the blood vessel walls; and hydrochlorothiazide reduces fluid overload by promoting urine production. These actions synergistically work to lower blood pressure, reduce strain on the cardiovascular system, and decrease the risk of developing severe health-related complications like heart attack, stroke, and kidney failure.

Tribenzor is available in various dosages to cater to individual patient needs, including 20 mg/5 mg/12.5 mg, 40 mg/5 mg/12.5 mg, 40 mg/5 mg/25 mg, 40 mg/10 mg/12.5 mg, and 40 mg/10 mg/25 mg combinations. This range allows healthcare providers to tailor treatments based on previous medication history, response to therapy, and specific health conditions.

Patients prescribed Tribenzor should take it consistently, preferably at the same time each day, to maintain stable blood pressure levels. It can be taken with or without food and should be swallowed whole with water. Routine monitoring of blood pressure, kidney function, and electrolyte levels is crucial to adjust dosages and ensure safety, especially in patients with pre-existing health conditions or those taking other medications. Tribenzor should not be used during pregnancy due to risks to the unborn child and is contraindicated in patients with severe renal issues, anuria, or those allergic to any component of the medication. Potential side effects include dizziness, headache, and changes in electrolyte and kidney function, underscoring the importance of medical supervision.

What Are the Uses of Tribenzor?

• Olmesartan medoxomil
• Amlodipine
• Hydrochlorothiazide

What Are the Forms & Strengths of Tribenzor?

Tribenzor is available in several combination dosages of its three active ingredients: amlodipine, olmesartan, and hydrochlorothiazide. Here are the forms and strengths in which Tribenzor is typically available:

• 20 mg/5 mg/12.5 mg
• 40 mg/5 mg/12.5 mg
• 40 mg/5 mg/25 mg
• 40 mg/10 mg/12.5 mg
• 40 mg/10 mg/25 mg

What Are the Recommended Dosage of Tribenzor?

The recommended dosage of Tribenzor, which combines amlodipine, olmesartan, and hydrochlorothiazide, can vary depending on several factors, including the patient’s response to treatment, existing health conditions, and previous treatments. Here’s a general guide on how Tribenzor is typically dosed:

Adults

• Starting Dosage: Typically, Tribenzor is prescribed when individual components (amlodipine, olmesartan, and hydrochlorothiazide) have been used first to establish tolerance and need. The starting dose can depend on the dosages of these individual components the patient was previously taking.
• Maintenance Dosage: Adjustments may be made based on the blood pressure response, usually not more frequently than once every 2-4 weeks. The doctor might increase the dose if the desired blood pressure goal isn’t achieved.

Elderly Patients

• Elderly patients may start on a lower dose due to potentially increased sensitivity to the medication and a higher likelihood of kidney or liver function impairment. The healthcare provider will closely monitor the response and adjust the dosage accordingly.

Patients with Renal or Liver Impairment

• Mild to Moderate Renal Impairment: Practice caution, and starting with a lower dose may be considered as hydrochlorothiazide and olmesartan are excreted via the kidney.
• Severe Renal Impairment or Dialysis: Tribenzor is generally not recommended due to hydrochlorothiazide, which requires renal excretion and may not be effectively cleared in these patients.
• Liver Impairment: Individuals with mild to moderate liver issues should also start with a lower dosage due to the slower metabolism of the drug components, particularly amlodipine.

Special Considerations

• Avoid in Pregnancy: Tribenzor is contraindicated during pregnancy due to the danger of harm to the unborn baby associated with the use of olmesartan.
• Monitor Electrolytes: Patients should monitor their electrolytes, as imbalances can occur, especially with hydrochlorothiazide.
• Maximum Dosage: so on

[Note: These recommendations may vary from person to person. Discuss them with your doctor, and they’ll customize your dosage accordingly.]

How to Use Tribenzor? 

• Always take Tribenzor precisely as your healthcare provider prescribes it. Do not change the dose or frequency without first consulting your doctor.
• Tribenzor is typically taken once a day. Try to take it simultaneously each day to maintain an even level of medication in your blood.
• Tribenzor can be taken with or without food. If you experience stomach upset with the medication, try taking it with food.
• Do not crush, chew, or break the Tribenzor tablet. Swallow it whole with a glass of water.
• Since Tribenzor contains a diuretic component, it is important to stay adequately hydrated. Discuss with your healthcare provider how much fluid you should consume daily.
• Routine check-ups with your healthcare specialist are essential to monitor your blood pressure and adjust the medication as needed. Keep track of your blood pressure readings and share them with your doctor during your visits.
• If you miss a dose, take it as soon as you remember. However, if it’s close to the time of your next dose, skip the missed dose & resume your regular schedule. Do not take two doses at once.
• Especially in the beginning stages of treatment or when the dose is adjusted, stand up slowly from a sitting or lying position. This medication can cause dizziness during sudden changes in posture.
• Do not stop taking Tribenzor without first discussing it with your healthcare expert. Sudden discontinuation of the medicine can lead to a rebound increase in blood pressure.

[Note: Your doctor will decide the correct dosage amount for you based on your health condition, following guidelines & studies on the drug. They’ll further adjust it as needed over time.]

How Does Tribenzor Work?

Tribenzor works by combining three different medications that help manage high blood pressure, each acting through a unique mechanism:

• Olmesartan: This is an angiotensin II receptor blocker (ARB). It functions by disrupting the action of angiotensin II, a chemical in your body that causes blood vessels to tighten and narrow. By blocking this effect, olmesartan helps blood vessels relax and widen, lowering blood pressure.
• Amlodipine: A calcium channel blocker that relaxes the muscles of the heart and blood vessels. It achieves this by preventing calcium from entering the cells of the heart & arteries, which helps to lower blood pressure levels and can also reduce chest pain (angina).
• Hydrochlorothiazide: It is a thiazide diuretic, often referred to as a water pill. It helps reduce blood pressure by flushing excess salt and water from the body through urine. This lowers the volume of blood that needs to pass through the blood vessels, easing pressure on the walls of the ship.

Important Safety Information for Using Tribenzor

What Are the Side Effects of Tribenzor?

Tribenzor may cause side effects, typically transient and lasting a few days to weeks. You must consult your doctor or pharmacist if these side effects persist, become bothersome, or intensify. Common side effects of Tribenzor can include:

• Dizziness
• Headache
• Fatigue
• Swelling of the ankles, feet, or hands (edema)
• Nausea
• Muscle spasms
• Back pain
• Joint pain
• Upper respiratory tract infection
• Urinary tract infection
• Increased urination
• Flu-like symptoms
• Rash
• Dry mouth
• Diarrhea or constipation
• Abdominal pain

Tribenzor can cause serious side effects, which are less common but may require immediate medical attention. If you experience any of the following serious side effects, seek medical help right away:

• Severe Hypotension (Low Blood Pressure): Symptoms may include extreme dizziness, fainting, or lightheadedness, especially when standing up.
• Worsening Chest Pain or Heart Attack: New or increasing chest pain might indicate a heart attack or angina, particularly in people with existing heart disease.
• Kidney Problems: Signs include a decrease in urine output, swelling in your feet or ankles, and feeling unusually tired or short of breath, which could indicate worsening kidney function.
• Electrolyte Imbalances: Symptoms such as severe dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pain or cramps, muscular fatigue, low blood pressure, producing less urine, nausea, and vomiting.
• Vision Changes: Sudden visual problems, a sign of acute myopia or angle-closure glaucoma, requiring urgent treatment.
• Allergic Reactions: A swollen face, lips, tongue, or throat, difficulty breathing, or hives indicate a severe allergic reaction.
• Lupus-like Syndrome: New or worsening joint pain, a rash on the cheeks or arms that worsens in the sun, fatigue, or fever could indicate a lupus-like syndrome triggered by the medication.

[Note: Remember, this list does not cover all possible side effects of Tribenzor. Always consult your healthcare expert for medical advice regarding the medication side effects.]

Are There Any Warnings for Tribenzor? 

Tribenzor poses several serious health risks, particularly for specific groups. Consult your doctor or pharmacist if you have concerns or are considering alternative treatments.

• Risk Warning: Not for Use During Pregnancy Tribenzor is contraindicated during pregnancy as it may cause severe, potentially fatal harm to the unborn baby. If you are pregnant or plan to become pregnant, discuss alternative blood pressure treatments with your healthcare provider. Stop using Tribenzor immediately if you are pregnant, and inform your doctor.
• Low Blood Pressure: Common factors that increase the risk include dehydration, prolonged diarrhea or vomiting, low sodium levels, high doses of diuretics, or aortic stenosis. Initial use or an increase in dose may cause significant drops in blood pressure, manifesting as dizziness or fatigue. Maintain adequate hydration to mitigate this risk. Contact your healthcare expert if you experience severe dizziness or fainting, especially after a fall or head injury.
• Risk of Heart Attack or Chest Pain: Individuals with severe coronary artery disease may experience worsening chest pain or a heart attack when starting Tribenzor or increasing the dosage. Reach out for medical attention right away if you have chest pain, pressure, heartburn, dizziness, or difficulty breathing.
• Worsening Kidney Problems: Tribenzor can impair kidney function, which is an elevated risk in individuals with pre-existing kidney issues or heart failure. Regular lab tests are essential to monitor kidney health. Report any reduction in urine frequency to your provider, as it may indicate deteriorating kidney function.
• Changes in Electrolyte, Blood Sugar, and Cholesterol Levels: Tribenzor may alter levels of electrolytes, blood sugar, and lipids, necessitating frequent blood tests. Inform your provider of all medications you’re taking and report symptoms like rapid heartbeat, muscle pain, weakness, nausea, or vomiting, which could indicate serious electrolyte imbalances.
• Vision Problems: Tribenzor’s hydrochlorothiazide component can cause acute vision changes or eye pain. Immediately report any vision alterations to your provider. Discontinue use & seek urgent medical attention if symptoms persist, as surgical intervention may be necessary to prevent permanent vision loss.
• Lupus: Hydrochlorothiazide in Tribenzor may trigger or exacerbate lupus. Alert your provider if you experience extreme joint pain, fatigue, or a butterfly-shaped rash on the face indicative of lupus symptoms.

What Are the FDA Boxed Warning for Tribenzor?

Tribenzor carries an FDA-boxed warning regarding the risk of harm to an unborn baby when used during pregnancy. The specific warnings include:

• Harm to Unborn Babies: Tribenzor contains olmesartan, a drug known to cause injury or death to a developing fetus when taken during the second & third trimesters of pregnancy. Exposure to olmesartan can lead to fetal toxicity, including hypotension, neonatal skull hypoplasia, anuria, renal failure, and death.

Due to these risks, pregnant women are advised not to take Tribenzor, and women of childbearing age should be informed about the potential hazards to the fetus. If pregnancy is detected during treatment, Tribenzor should be discontinued as soon as possible. Alternative antihypertensive treatments that have safer profiles during pregnancy should be considered.

What Are the Tribenzor Precautions?

When taking Tribenzor, it’s essential to consider several precautions to ensure safe and effective medication use. Here are the essential precautions:

• Blood Pressure Monitoring: Routine blood pressure monitoring is crucial to ensure that Tribenzor effectively controls your blood pressure without causing it to drop too low.
• Electrolyte Imbalance: Tribenzor can affect your body’s electrolyte balance, leading to low levels of potassium, magnesium, and sodium. Your healthcare expert may recommend periodic blood tests to monitor your electrolyte levels.
• Kidney Function: Since Tribenzor can affect kidney function, your provider may conduct regular kidney function tests, especially if you have existing kidney issues.
• Pregnancy and Breastfeeding: Tribenzor is not prescribed during pregnancy due to the chances of harm to the unborn baby. Discuss with your healthcare specialist if you are pregnant or planning to become pregnant. It’s also advisable to talk about breastfeeding as it’s unclear if the components of Tribenzor pass into breast milk.
• Allergic Reactions: Inform your healthcare specialist if you have a history of allergic reactions to any component of Tribenzor, especially if you have had allergies to sulfa drugs, as this medication contains hydrochlorothiazide, a sulfa derivative.
• Avoid Alcohol: Alcohol can enhance the blood pressure-lowering effects of Tribenzor and increase the risk of side effects such as dizziness and fainting.
• Surgery or Anesthesia: If you are scheduled for surgery or are to receive anesthesia, inform your surgeon or anesthesiologist that you are taking Tribenzor, as it may affect blood pressure control during and after the procedure.
• Dizziness and Light-headedness: Be cautious when standing up from a sitting or lying position, as Tribenzor can cause dizziness and light-headedness due to blood pressure changes.

What Are the Contraindications of Tribenzor? 

The contraindications for using Tribenzor include:

• Pregnancy: Tribenzor is contraindicated during pregnancy due to the risk of harm or death to the developing fetus, particularly from the olmesartan component, which can cause fetal toxicity.
• Hypersensitivity: Any previous hypersensitivity reactions to amlodipine, olmesartan, hydrochlorothiazide, or any other component of Tribenzor preclude its use. This includes conditions such as angioedema related to prior treatment with an angiotensin receptor blocker (ARB) or angiotensin-converting enzyme (ACE) inhibitor.
• Anuria: Patients who are unable to produce urine (anuria) should not use Tribenzor, mainly due to the hydrochlorothiazide component.
• Severe Renal Impairment: Tribenzor should be used with caution or avoided in patients with severe kidney issues, where the drug’s effects can exacerbate the condition.

What If You Missed a Dose of Tribenzor?

If you miss a dose of Tribenzor, take it as soon as you remember. However, if it’s close to your next scheduled dose of Tribenzor, skip the missed dose & continue with your routine dosing schedule. Do not take two doses of this medicine at once to make up for a missed dose, as this can lead to potential overdose symptoms or increased side effects. It’s essential to take Tribenzor consistently to maintain adequate blood pressure control. If you frequently miss doses, consider setting reminders or alarms to help ensure you take your medication as prescribed. Always discuss any concerns about missed doses or how to manage missed doses with your healthcare provider.

[Note: If you have missed a dose of Tribenzor and are unsure when to take the next dose, quickly consult your doctor or pharmacist.]

What Happens If You Take Too Much of Tribenzor?

Taking too much Tribenzor can lead to serious complications due to an excessive drop in blood pressure and other severe side effects. Symptoms of an overdose might include extreme dizziness, fainting, rapid or unusually slow heartbeat, and possibly confusion or disorientation. In severe cases, an overdose of Tribenzor could result in shock or organ failure due to prolonged low blood pressure. If you suspect that you or someone else has taken an overdose of Tribenzor, it’s crucial to seek emergency medical attention immediately. Provide the healthcare professionals with as much information as possible, such as how much was taken and when. Prompt medical intervention is crucial to manage the symptoms effectively and prevent possible long-term damage.

[Note: If you have consumed more than the recommended dose of Tribenzor, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

How to Store a Tribenzor?

To ensure that Tribenzor remains effective and safe for use, follow these storage guidelines:

• Store Tribenzor at room temperature, usually between 20°C to 25°C.
• Keep the medication away from excessive moisture and light. Do not store it in the bathroom or near a sink; avoid places exposed to high humidity or direct sunlight.
• Keep Tribenzor in its original packaging until it is time to take the medication. This helps protect it from environmental conditions and ensures it does not get mixed up with other medicines.
• Store Tribenzor out of reach of children and pets to prevent accidental ingestion.
• Regularly check the expiration date on the Tribenzor packaging, and do not use the medication past this date. Dispose of expired or unused medicines properly, following guidelines to ensure they do not harm others or the environment.

[Note: Discuss with your healthcare expert the proper disposal of unused medication and any questions you may have regarding its storage.]

What Medications Interact with Tribenzor?

Tribenzor, which combines amlodipine, olmesartan, and hydrochlorothiazide, may interact with several medications. Here are some fundamental interactions to be aware of:

• NSAIDs (Nonsteroidal Anti-Inflammatory Drugs): Medications like ibuprofen and naproxen can reduce the effectiveness of Tribenzor and increase the risk of kidney damage.
• Lithium: Tribenzor can increase lithium levels in your blood, potentially leading to lithium toxicity.
• Aliskiren: If you have diabetes or kidney problems, combining Aliskiren with Tribenzor can increase your risk of kidney damage, low blood pressure & high potassium levels.
• Other Blood Pressure Medications: Using other antihypertensives with Tribenzor may cause excessively low blood pressure.
• Steroids: Can reduce the effectiveness of Tribenzor and increase the risk of electrolyte imbalances.
• Alcohol, Barbiturates, Narcotics, or Antidepressants: These can potentiate the hypotensive effects of Tribenzor and increase dizziness.
• Cholestyramine and Colestipol: These can decrease the absorption of hydrochlorothiazide and reduce its effectiveness.
• Diabetes Medications: Tribenzor may affect blood glucose levels, requiring adjustments in diabetes medication dosages.
• Supplements like Potassium: Since Tribenzor contains a diuretic, supplements or salt substitutes containing potassium can lead to seriously high potassium levels in your blood.

What Are the Other Tribenzor Interactions?

Tribenzor may interact with various substances, affecting how well the medication works or increasing the risk of side effects. Here are some notable interactions:

• Alcohol: Consumption can enhance the blood pressure-lowering effects of Tribenzor, leading to increased dizziness or risk of fainting.
• NSAIDs (Non-Steroidal Anti-Inflammatory Drugs): Medications like ibuprofen and naproxen can reduce the effectiveness of Tribenzor and potentially increase the risk of kidney problems.
• Supplements: Potassium supplements and salt substitutes containing potassium can elevate the risk of high potassium levels when taken with Tribenzor, mainly due to the presence of the ACE inhibitor component.
• Other Blood Pressure Medications: Using Tribenzor with other drugs that lower blood pressure can enhance the effects, potentially causing blood pressure levels to drop too low.
• Lithium: Tribenzor can increase lithium levels in the blood, enhancing its effects and side effects.
• Steroids: Can reduce the effectiveness of Tribenzor in lowering blood pressure.
• Diabetes Medications: Tribenzor can alter the blood sugar-lowering effects of diabetes medications, requiring adjustments in doses.
• Cholestyramine and Colestipol: These cholesterol medications can decrease the absorption and effectiveness of Tribenzor.

[Note: This is not a complete list of Tribenzor, and there could be other drugs that interact with Tribenzor. Make sure to tell your doctor about any prescription, over-the-counter, or herbal products you’re taking.]

What Are the Tribenzor Alternatives?

Tribenzor is a combination medication containing olmesartan (an angiotensin II receptor blocker), amlodipine (a calcium channel blocker), and hydrochlorothiazide (a thiazide diuretic). It’s used to treat high blood pressure. Here are some alternatives:

Other combination medications:

• Exforge HCT (valsartan/amlodipine/hydrochlorothiazide)
• Tekturna HCT (aliskiren/hydrochlorothiazide)
• Azor (olmesartan/amlodipine)
• Hyzaar (losartan/hydrochlorothiazide)

Single-component medications:

• ARBs: Cozaar (losartan), Diovan (valsartan), Avapro (irbesartan)
• ACE inhibitors: Zestril (lisinopril), Altace (ramipril), Vasotec (enalapril)
• Calcium channel blockers: Norvasc (amlodipine), Cardizem (diltiazem)
• Diuretics: Microzide (hydrochlorothiazide), Lasix (furosemide)
• Beta-blockers: Toprol-XL (metoprolol), Coreg (carvedilol)

Other classes of blood pressure medications:

• Alpha-blockers: Cardura (doxazosin)
• Direct renin inhibitors: Tekturna (aliskiren)
• Central-acting agents: Catapres (clonidine)

Non-pharmacological approaches:

• Dietary changes (e.g., reducing sodium intake)
• Regular exercise
• Weight loss (if overweight)
• Stress management techniques

[Note: Your doctor will choose the most suitable Tribenzor alternative. Don’t use any of these alternative medications without medical supervision. Taking them on your own may cause serious side effects.]

Tribenzor Cost & Coupons

Tribenzor is a powerful option for controlling high blood pressure, but the high retail prices in the US can be challenging for many patients. US residents can consider purchasing Tribenzor from Canadian pharmacies for more affordable alternatives. Polar Bear Meds is a trusted source renowned for its competitive medication pricing. By using the coupon code “WELCOMEPB10” at checkout, customers can avail up to a 10% discount on their first order. Additionally, our referral program provides extra savings, including a free coupon for future purchases. Secure your Tribenzor supply from Canada and benefit from significant cost savings.

Frequently Asked Questions

How Can I Tell If Tribenzor Is Effective?

To determine if Tribenzor is effective, consistently measure your blood pressure at home and log the results. Share these readings with your healthcare expert during your visits to evaluate the medication’s effectiveness. It’s important to continue taking Tribenzor as prescribed, even if you don’t feel any immediate effects, because controlling your blood pressure is critical in preventing severe health complications like heart attacks, strokes, and heart failure.

Should I Consider Starting Tribenzor If I Have Recently Been Diagnosed With High Blood Pressure?

Tribenzor is generally not the first choice for those who have just been diagnosed with high blood pressure. Simultaneously, initiating treatment with all three components of Tribenzor—amlodipine, olmesartan, and hydrochlorothiazide—may lower your blood pressure too much, potentially leading to adverse effects like dizziness. However, if you have previously been treated with multiple blood pressure medications, your provider may consider Tribenzor suitable. It’s important to consult with your healthcare professional to determine if Tribenzor is an appropriate option for managing your blood pressure.

Can I Use Tribenzor If I Have Kidney Issues?

If you have kidney issues, discussing this with your medical specialist before starting Tribenzor is important. While components such as amlodipine, hydrochlorothiazide, and ARBs like those found in Tribenzor have been shown to slow the occurrence of kidney damage in early chronic kidney disease (CKD), Tribenzor may not be suitable for everyone with kidney conditions. This is due to the potential for ARBs to exacerbate kidney problems and for thiazide diuretics to alter electrolyte balances. Conditions like renal artery stenosis or severe heart failure could also influence the safety of using Tribenzor. Given your kidney health, your healthcare provider can help determine if Tribenzor is a safe & effective option for managing your blood pressure.

Is it safe to take Tribenzor during pregnancy?

You should avoid taking Tribenzor if you are pregnant. The medication includes olmesartan, which has been shown to cause significant harm to an unborn baby when used during pregnancy. Additionally, Tribenzor contains hydrochlorothiazide and amlodipine, which have not been thoroughly researched regarding their safety in pregnancy. While hydrochlorothiazide may be used in low doses under certain conditions, it poses risks, such as altering electrolyte balances. If you are pregnant or planning to become pregnant, consult your healthcare provider to explore safer alternatives for managing your condition.

Our Guarantee

At PolarBearMeds.com, we assure you that you get the most affordable price to buy Tribenzor online from Canada. Rest assured, knowing that the medication you ordered will be dispatched and delivered from a reputable licensed Canada Pharmacy Online, abiding by the highest standards of quality and authenticity. Our discounted medications are Xpress shipped directly from Canada to your doorstep, ensuring a swift & secure delivery experience. To conveniently buy Tribenzor online at a substantial cost, call us at 1-888-779-2193 toll-free.