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What is Is Colchicine (Colcrys)?

Colchicine, often sold under the brand name Colcrys, is a medication used to treat gout flares and familial Mediterranean fever (FMF). It belongs to a class of drugs known as anti-gout agents. The recommended dosages vary based on the condition. 

Dosage and Uses of Colchicine

Understanding the appropriate dosage and its various applications is essential for safe and effective use. A lower dose may be prescribed for individuals with kidney or liver disease. Also, patients with kidney or liver disease may require regular monitoring of blood and urine tests.


The recommended dosage of Colcrys (Colchicine) varies based on the specific condition being treated. Colchicine 0.6 mg price and Colchicine 0.5 mg price may vary depending on the brand, location, and available discounts.

Gout Treatment:

  • Usual dose is 1 tablet (500 micrograms) taken 2 to 4 times daily.
  • Administer whole tablets with water.
  • The duration of treatment for gout typically spans a few days.

Familial Mediterranean Fever (FMF):

  • Dosage ranges from 1 to 4 tablets (500 micrograms to 2mg) taken once daily.
  • Tablets should be swallowed whole with water.
  • Long-term use is often recommended for FMF.


  • Gout Treatment: Effectively alleviates severe joint pain and inflammation associated with gout attacks.
  • Preventative Measure: It can be used to prevent future gout attacks.
  • Chronic Conditions: Long-term use may be advised for individuals with chronic gout or familial Mediterranean fever (FMF).
  • Medical Supervision: Always take under the guidance and supervision of a healthcare practitioner due to potential side effects and interactions with other medications.

How to Store Colchicine (Colcrys)?

Proper storage of Colchicine (Colcrys) is crucial to maintain its effectiveness and safety. Here are some guidelines to ensure appropriate storage:


  • Store at room temperature.
  • Keep it away from direct light and moisture.
  • Regularly check for and discard any expired or unneeded medication.


  • Avoid storing it in the bathroom, as moisture and temperature fluctuations can affect the medication’s stability.
  • By adhering to these recommendations, you can safeguard the integrity and potency of your Colcrys medication, ensuring its optimal therapeutic benefits.

How Does Colchicine Work?

Colchicine exerts its therapeutic effects by interfering with the inflammatory process at a cellular level. Specifically, it disrupts the function of microtubules, which are tiny structures within cells that play crucial roles in various cellular processes.

Here’s a detailed breakdown of how Colchicine works:

Inhibition of Microtubule Function: Colchicine binds to a protein called tubulin, which is a key component of microtubules. By binding to tubulin, Colchicine disrupts the assembly of microtubules and prevents their proper functioning.

Cellular Effects: Microtubules are essential for several cellular functions, including cell division, intracellular transport, and maintenance of cell shape. When Colchicine disrupts microtubule function, it affects these processes.

Anti-Inflammatory Action: In the context of conditions like gout, Colchicine’s interference with microtubules has an anti-inflammatory effect. It inhibits the movement of certain white blood cells (neutrophils) to the site of inflammation, reducing their activity and the subsequent inflammatory response.

Gout Treatment: In gout, uric acid crystals accumulate in the joints, leading to intense inflammation and pain. Colchicine helps alleviate this by reducing the inflammation caused by the presence of these crystals.

Other Medical Uses: Apart from gout, Colchicine is also used to treat conditions like familial Mediterranean fever and pericarditis, where its anti-inflammatory properties are beneficial.

Colcrys vs. Mitigare

Colcrys and Mitigare are both used for the treatment of gout, with similar efficacy and side effects. Understanding the differences between the two can help patients make informed decisions. Here are the key points to consider:

  • Cost: Colcrys is a patented medication. Both Colchicine 0.6 mg price and Colchicine 0.5 mg price tends to be more than Mitigare, which is a generic form of colchicine. Choosing Mitigare may be more cost-effective for some patients.
  • Accessibility: Mitigare is more accessible due to its lower cost and availability as a capsule.
  • Dosage and Frequency: Colcrys is taken 2-4 times daily, while Mitigare is usually taken once a day.
  • Indications: Both medications can be used for acute gout flares and prophylaxis, as well as for other conditions such as familial Mediterranean fever, Behçet’s disease, pericarditis, and pseudogout.

Ultimately, it is best to consult a healthcare provider to determine the most suitable medication option based on individual needs and preferences.

Side Effects of Colcrys

Colcrys (Colchicine) may cause various side effects, though not everyone will experience them. It’s crucial to promptly report any unusual or severe reactions to a healthcare professional. Here are potential side effects associated with Colcrys:

  • Nausea and Vomiting
  • Diarrhea
  • Abdominal Pain
  • Muscle Pain
  • Weakness and Fatigue
  • Headache
  • Dizziness or Lightheadedness
  • Hair Loss
  • Unusual Bleeding or Bruising
  • Fever, persistent sore throat, or unusual tiredness.
  • Muscle Weakness or Pain

Warnings and Precautions of Colcrys usage

Here are the warnings and precautions associated with Colcrys (Colchicine):

  1. Some individuals may be allergic to Colchicine. Seek immediate medical help if you face symptoms like rash, itching, severe dizziness, or difficulty breathing.
  2. Take Colcrys exactly as prescribed by your healthcare practitioner. Please do not alter the dosage or stop taking it without consulting your doctor.
  3. Tell your healthcare practitioner if you have any liver or kidney problems.
  4. Colcrys can affect blood cells, so inform your healthcare practitioner if you have any blood-related conditions.
  5. Report any unusual muscle weakness or pain, particularly if accompanied by dark urine or changes in urine output.
  6. Inform your healthcare practitioner about all medications, supplements, and herbal products you are taking. Certain drugs can interact with Colcrys, potentially leading to adverse effects.
  7. If you are pregnant or breastfeeding, discuss this with your healthcare practitioner.
  8. Special caution is advised when using Colcrys in children and elderly individuals, as they may be more susceptible to side effects.
  9. Colcrys may cause dizziness or drowsiness. 
  10. Limit or avoid alcohol while taking Colcrys. Additionally, avoid grapefruit or grapefruit juice, as it can interact with the medication.
  11. Inform your healthcare practitioner about any pre-existing medical conditions, especially if you have heart problems, gastrointestinal disorders, or if you are prone to allergic reactions.
  12. Your healthcare practitioner may conduct periodic tests to monitor your response to Colcrys and to check for any potential side effects.

Colcrys Interactions

A total of 256 medications have been identified as potentially interacting with Colcrys, as well as 1 alcohol/food interaction and 7 disease interactions. Some of the medications are Cyclosporine, Clarithromycin, Statins (e.g., Atorvastatin, Simvastatin), and Verapamil. It interacts with conditions like liver disease, kidney disease, gastrointestinal disorders, cardiovascular disease, blood disorders, muscle disorders, and allergies.

These interactions can range in severity from major to minor or even unknown, making it important to consult a healthcare practitioner before starting or stopping any medication. Doing so will help prevent potentially harmful interactions and optimize health outcomes.

Frequently Asked Questions

Can I purchase Colcrys online from Canada without a prescription?

It is not possible to purchase Colcrys online from Canada without a prescription. As it is a prescription medication, it requires a valid prescription from a healthcare professional for legal acquisition.

How can I ensure the authenticity and safety of the Colcrys medication purchased online from Canada?

To ensure the authenticity and safety of Colcrys medication purchased online from Canada, verify the credentials of the online pharmacy, check for proper licensing, read customer reviews, and consult a healthcare professional prior to purchase. You will find all of this information available on

Are there any specific regulations or restrictions when ordering Colcrys from Canada?

When ordering Colcrys from Canada, it is essential to ensure that the online pharmacy is reputable, licensed, and requires a valid prescription. Additionally, all customs regulations and importation laws should be adhered to.

Are there any alternative medications or treatments for gout that can be purchased online from Canada?

Alternative medications and treatments for gout that can be purchased online in Canada include NSAIDs such as ibuprofen, corticosteroids, and urate-lowering therapies like allopurinol or febuxostat. To ensure safe and effective use, it is important to consult a healthcare professional before beginning any new medication.

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