Insulin Lispro and Insulin Lispro Protamine

Humalog Mix 25 Kwikpen 

Humalog Mix 25 Kwikpen is an insulin delivery device containing insulin lispro protamine and insulin lispro approved by the FDA for managing diabetes. It offers a balance of rapid and extended blood sugar control. It is administered 15 minutes before meals via subcutaneous injection, and the dosage varies based on individual insulin needs and meal timing. Proper storage between 36°F and 46°F (2°C to 8°C) preserves its effectiveness, with room temperature storage allowed for up to 28 days. You must adhere to precise dosing instructions to prevent underdosing or overdosing and rotate injection sites to avoid tissue damage. Consulting healthcare providers before use and regular blood sugar monitoring are crucial for safe and effective treatment.

Product Overview

Humalog Mix 25 Kwikpen is an FDA-approved insulin delivery device containing a specific mixture of insulin lispro protamine suspension and insulin lispro injection, which are its active ingredients. It is used to help manage blood sugar levels in people with diabetes. It is formulated to provide both rapid-acting and intermediate-acting insulin coverage in a single injection, making it suitable for controlling blood sugar levels throughout the day. 

The ratio of insulin lispro protamine suspension to insulin lispro injection in each dose is 25/75, providing a balanced approach to controlling blood glucose fluctuations. The usage of the Humalog Kwikpen Mix 25 involves dialing the prescribed dose accurately and injecting it subcutaneously 15 minutes before or immediately after meals. The dosage requirements may vary depending on individual factors such as diet, physical activity, and current blood sugar levels. 

It should be stored in the refrigerator between 36°F to 46°F (2°C to 8°C) when not in use. You should avoid sharing the device with others to prevent cross-contamination and safely discard used needles to minimize the risk of needlestick injuries. If you are using Humalog Mix 25 Kwikpen, you should be aware of signs of hypoglycemia or hyperglycemia and seek medical attention if necessary.

What Are the Uses of Humalog Mix 25 Kwikpen?

It is used to improve glycemic control in patients with:  

• Type 1 diabetes mellitus
• Type 2 diabetes mellitus

What Are the Forms & Strengths of Humalog Mix 25 Kwikpen?

Kwikpen Humalog Mix 25 is a prefilled pen device for subcutaneous injection. Each milliliter (ml) of Humalog Mix 25 Kwikpen contains:

• 100 units of insulin lispro protamine suspension (25%)
• 100 units of insulin lispro (75%)

What Is the Recommended Dosage of Humalog Mix 25 Kwikpen?

Humalog Mix 25 dosage is based on the patient’s blood medical condition, age, lifestyle, and response to the treatment. It is typically administered subcutaneously twice daily, within 15 minutes before meals. A healthcare provider determines the initial dose, considering factors like previous insulin use and current glycemic control. Regular monitoring and professional guidance are crucial for dose adjustments to maintain optimal blood sugar levels. If your doctor has prescribed you a dose different than the one given below, do not make adjustments to the dosage without consulting your medical team. 

For Type 1 Diabetes

The recommended dosage depends on various factors, including individual needs and metabolic requirements. However, a common starting dose typically ranges from 0.5 to 1 unit per kilogram of body weight per day.

For Type 2 Diabetes 

The specific dose will depend on your doctor’s recommendations. However, a typical starting dose for type 2 diabetes is approximately 0.1 to 0.2 units per kilogram of body weight per day.

[Note: It’s crucial to work closely with your healthcare provider to determine the appropriate dosage of Humalog Mix 25 Kwikpen based on your individual needs].

How to Use Humalog Mix 25 Kwikpen?

Before using Humalog Kwikpen Mix 25, you should carefully read and follow the instructions for use given in the medication guide & patient information leaflet to ensure a safe and efficient use of the medication. If you have any queries or concerns regarding using the Kwikpen or if you have difficulty understanding any part of the leaflet, ask your medical team. Make sure you and your caregiver understand how to properly administer the insulin. Your doctor will show you how to prepare and administer the insulin the first time, ensure that you understand it. Taking Humalog Mix 25 Kwikpen involves several steps to ensure proper administration:

Step 1. Start by washing your hands thoroughly with soap and water to prevent contamination and taking out the Humalog Mix 25 Kwikpen from its packaging. Do not use an insulin that is cold or frozen, as it can be painful. If the insulin inside your kwikpen is frozen, do not use it; discard it in a sharps disposal container. 

Step 2. Choose an injection site on your body, such as the abdomen, thigh, or upper arm. Rotate injection sites to prevent tissue damage. Do not inject into a skin area that is damaged, torn, scaly, red, or has stretch marks. Do not inject into a vein or muscle, as it can cause hypoglycemia. Clean the chosen area with an alcohol swab and allow it to dry. The medication dosage is based on the medical condition being treated, age, and patient’s response to treatment. 

Step 3. Check the Humalog Mix 25 Kwikpen for any visible signs of damage or leakage. Ensure the insulin appears clear and colorless; do not use it if it appears cloudy or discolored. After mixing, this insulin should look evenly cloudy and milky. Do not use it if you notice particles inside it or clumps of white material.

Step 4. If you are using the pen for the first time or if you haven’t used it for a while, you may need to prime it. Priming removes any air bubbles and ensures the correct dosage. Follow the manufacturer’s instructions for priming. Do not shake the container. 

Step 5. Turn the dose selector to the number of units prescribed by your healthcare provider. Double-check the dose to ensure accuracy, as even small changes in the insulin amount may have a large effect on the levels of your blood sugar levels.

Step 6. Pinch the cleaned skin at the injection site and insert the needle at a 90-degree angle under the skin. Press the button to deliver the insulin and hold the pen in place for a few seconds to ensure the total dose is administered. Do not remove the needle too quickly to avoid insulin leakage. Do not rub the injection spot after injecting the medication. 

Humalog Mix 25 is used alongside a proper diet and exercise treatment program to regulate blood sugar levels in patients with diabetes mellitus. You are required to inject this insulin twice daily, fifteen minutes before the morning and evening meal. Since Humalog Mix 25 Kwikpen is short-acting insulin, not eating right after administering the medication may lead to hypoglycemia. 

Do not mix it with other insulins or use it in an insulin pump. Do not change your types or brands without consulting your doctor, as it can cause unwanted side effects. To get the most benefit from your medication, you should take it at the same time every day and maintain consistency in dosage. Tell your doctor if your condition does not get better or if it worsens. 

[Note: If you have any questions or concerns about injection technique or site selection, consult your healthcare provider or diabetes educator for guidance on administering Humalog Mix 25 Kwikpen].

How Does Humalog Mix 25 Kwikpen Work?

Kwikpen Humalog Mix 25 combines two types of insulin analogs: Insulin lispro and insulin lispro protamine. Insulin lispro acts rapidly to regulate post-meal blood sugar spikes. Insulin lispro protamine has a slower onset and prolonged duration, providing basal insulin coverage. When injected, the rapid-acting component addresses immediate glucose elevation, while the intermediate-acting component helps maintain steady levels between meals. This dual-action approach offers more comprehensive and consistent blood sugar control throughout the day, aligning with natural insulin secretion patterns and enhancing overall glycemic management for individuals with diabetes.

Important Safety Information for Using Humalog Mix 25 Kwikpen

Does Humalog Mix 25 Kwikpen have any side effects?

Common Side Effects of Humalog Mix 25 Kwikpen: Similar to other medications, Kwikpen Humalog Mix 25 can cause certain side effects in some people using it. However, not everyone using it will experience them. Most of the side effects caused by Humalog are not serious and disappear on their own within a few days or weeks as your body starts to adjust to the medication. If you are concerned about using Humalog Mix 25, you should consult your doctor beforehand, and they will help you prevent it. Some common side effects of Humalog Mix 25 Kwikpen are as follows:

• Headache: It is possible to experience headaches while using this medication, especially during the initial period. Headaches may occur because of hyperglycemia (high blood pressure), hypoglycemia (low blood pressure), or a sudden change in the levels of blood sugar in the body. They improve as soon as your blood sugar levels are stable. 
• Nausea: If your blood sugar levels are too high or too low, you may feel nauseous while using this medication. You should stick to your insulin schedule and drink plenty of fluids to prevent this. Call your doctor immediately if you have stomach issues such as reduced or no appetite, low blood sugar, or consistent vomiting or diarrhea.   
• Diarrhea: Diarrhea can occur due to diet or medication changes. Patients with type 1 diabetes, celiac disease, or geriatric people are more likely to experience diarrhea while using this medication. You should intake fluids and fiber and try not to stay dehydrated while using this medication. 
• Fatigue: Fatigue and weakness may result when the cells inside the body do not get enough sugar. You can also experience fatigue if you experience hyperglycemia or hypoglycemia, if you are taking certain medications, such as beta-blockers, or if you have chronic sleep interruptions. 
• Hypoglycemia: You may experience hypoglycemia or low blood sugar if you have injected medication more than prescribed, if you have not consumed enough amount of carbohydrates, or if you are exercising more than usual. Symptoms of hypoglycemia may include feeling like you may pass out, dizziness, irritability, or having blurred vision, or tremors. Hypoglycemia can be serious and can lead to immediate injury, coma, and even death if not treated promptly. 
• Injection site reactions: They may manifest as minor irritations and are most common when you start insulin therapy. They disappear on their own within a couple of days. You should rotate the injection spot every time you administer the insulin to prevent injection site reactions. Common symptoms of injection site reactions may include skin thickening, constipation, weight gain, sodium retention, and fluid retention. 

Mild Side Effects of Humalog Mix 25 Kwikpen: Sometimes, this medication can cause mild side effects in some users. Usually, these side effects are not serious and do not require medical attention. However, if they still persist or become bothersome, consult a licensed healthcare practitioner immediately and report any new or worsening symptoms to your doctor at once. Mild side effects of Humalog Mix 25 Kwikpen are given below: 

• Weight gain: Humalog may cause weight gain, as your body begins to absorb glucose again and converts any excess into fat. Weight gain may also occur if your treatment does not manage blood sugar levels properly and its levels are too high. 
• Hypokalemia (low potassium levels): This medication can cause a slight drop in the potassium levels as it helps transfer potassium into muscle and liver cells by increasing the activity of a specific pump. Hypokalemia can further increase the risk of cardiac arrest, arrhythmias, and respiratory muscle weakness.  
• Thickening or hollowing of the skin on the injection site or lipohypertrophy: This can happen when you inject insulin into the same area two or more times in a row. Its symptoms may include injection site skin feeling thicker and rubbery, appearing of swollen lumps, or the skin looking strange. To prevent this, you should rotate injection sites each time you inject the dose and use a new needle for each injection. 

Serious Side Effects of Humalog Mix 25 Kwikpen: In rare cases, Humalog Mix 25 can cause serious side effects in some users. The adverse side effects caused by this medication require immediate medical attention and can become fatal if not treated promptly. You should seek prompt medical assistance by calling 911 or your doctor if you experience any of the symptoms mentioned below. 

• Allergic reactions: These may range from minor to severe and can be caused by contamination of the kwikpen needle or its excipients. Its symptoms may include hives, redness, swelling, nausea, diarrhea, wheezing, and angioedema.  
• Lipodystrophy, such as fat loss (lipoatrophy) or fat buildup (lipohypertrophy) at the injection site
• Diabetic ketoacidosis (DKA): This condition may be caused when you are using an insulin pump that is not working properly. DKA is a fatal condition that can occur when the body breaks down fat too quickly, which can make the blood acidic. Its symptoms may include low insulin levels, serious illness, infection, injury, missing your medication dosage, and prolonged uncontrolled blood sugar. 

[Note: You should contact your doctor immediately if you experience severe side effects. Call 911 or your local emergency number if the Humalog Mix 25 Kwikpen side effects seem life-threatening].

Are There Any Warnings for Humalog Mix 25 Kwikpen?

While using Kwikpen Humalog Mix 25, there are certain warnings that you should consider. Some key points of the warning are as follows: 

Oedema: Your body retains fluid when you have oedema. The Humalog Mix 25 Kwikpen should be used with caution as it may cause oedema in some people.

Hypoglycemia: Sometimes, Humalog Mix 25 Kwikpen can cause hypoglycemia. You are especially at risk if you have kidney problems, are malnourished, or take medications that lower blood sugar levels. It may be recommended that you monitor your blood sugar levels regularly while on Humalog Mix 25 Kwikpen treatment.

Driving and Operating Machines: A low or high blood sugar level may affect your ability to drive a vehicle or operate a machine. You should avoid activities requiring mental alertness if you experience symptoms such as lightheadedness, blurred vision, etc. while taking Humalog Mix 25 Kwikpen.

Use with Other Insulin: It is not recommended to dilute or mix Humalog Mix 25 Kwikpen with any other insulin solution, as this may alter the effects of either drug when taken together and raise the risk of side effects.

Single-Person Use: Humalog Mix 25 Kwikpen should never be shared with others because it may transmit infection or disease.

Allergic Reactions at the Injection Site: Humalog Mix 25 Kwikpen may cause injection site reactions such as redness, pain, burning, inflammation, or hives (itchy, painful eruptions that sting). It is recommended to rotate the injection site continuously within a given area in order to prevent or reduce these reactions. It usually takes a few days to a few weeks for these reactions to resolve.

Use in Children: As the safety and efficacy data for Humalog Mix 25 Kwikpen are not clinically established, Humalog Mix 25 Kwikpen should not be used by children below 18 years of age.

Subcutaneous Use Only: Humalog Mix 25 Kwikpen can only be administered subcutaneously (under the skin). There is no need to help it intravenously (into the veins) or intramuscularly (into the muscles).

Pregnant: Tell your doctor immediately if you are pregnant, think you may be pregnant, or plan to become pregnant while using this medication. Pregnancy may cause or worsen or cause pregnancy. Your doctor may make changes to your medication dosage and diet during your pregnancy. 

Breastfeeding: Humalog Mix 25 passes into breastmilk, but is unlikely to harm the nursing infant. However, you should consult your doctor before breastfeeding. You may require dosage adjustment while breastfeeding. 

What Are the Humalog Mix 25 Kwikpen Precautions?

Before using Humalog Kwikpen Mix 25, you should share your complete medical and personal history with your doctor, especially if you have liver/kidney disease. You should also tell them about all the medications you are currently using or plan to use, including all prescription medications, non-prescription, over-the-counter drugs, and herbal or vitamin supplements. You should also keep in mind the following precautions associated with its use. 

• Always wash your hands before handling the Humalog Mix 25 Kwikpen to prevent contamination.
• Check the insulin’s appearance before each use; if it looks cloudy or discolored, do not use it.
• Never share your Kwikpen with others, as it is meant for your personal use only.
• Keep track of your blood sugar levels regularly as directed by your healthcare provider.
• Inform your healthcare provider about any changes in your diet, exercise routine, or medications.
• Rotate injection sites to avoid developing skin problems or lipodystrophy.
• Store the Kwikpen in the refrigerator when not in use, and keep it away from extreme heat or direct sunlight.
• If you are traveling, ensure proper storage of the Kwikpen and bring an adequate supply of insulin.

What Are the Contraindications for Humalog Mix 25 Kwikpen? 

The use of Humalog Mix 25 Kwikpen is contraindicated for use in cases when: 

• If you are hypersensitive to the primary active substance or any of the excipients in Humalog Mix 25 Kwikpen.
• If you are under 18 years of age
• If you are experiencing episodes of hypoglycemia.

What If You Missed a Dose of Humalog Mix 25 Kwikpen?

To get the most benefit from your medication, you should take it at the same time every day. Immediately inject a missed dose if you realize you have missed one soon after a meal. If much time has passed since your last meal, follow your doctor’s instructions. If a dose was missed, do not inject a double dose to make up for it. To further prevent missing doses, you can set a reminder on your phone. Medication reminders work best for this purpose. 

[Note: If you miss a dose of Humalog Mix 25 Kwikpen, follow the provided guidance and consult your doctor promptly if needed].

What Happens If You Take Too Much of Humalog Mix 25 Kwikpen?

Suppose an overdose of Humalog Mix 25 Kwikpen is injected. In that case, it may result in hypoglycemia (low blood sugar levels) with extreme fatigue, vision change, sweating, difficulty speaking, shaking, abdomen pain, drowsiness, etc. If you suspect a Humalog overdose, you should seek prompt medical attention. You can call your medical team, 911, or poison control helpline. You can also head to the nearest hospital.  

[Note: You can reach the American Association of Poison Control Centers at 800-222-1222. Call 911 or contact your healthcare provider if you have severe symptoms].

How to Store Humalog Mix 25 Kwikpen?

To ensure the potency and accuracy of your medication, you should follow proper storage and disposal procedures. You should keep it in the refrigerator or at room temperature, away from light, moisture, and heat, in its original packaging. Follow the guidelines below to ensure your medication’s safety and efficacy.

• Store unopened Humalog mix 25 Kwikpen in the refrigerator at 36°F to 46°F (2°C to 8°C) until the expiration date. Do not freeze.
• If needed, unopened Humalog mix 25 Kwikpen can be kept at room temperature (below 86°F or 30°C) for up to 28 days. Discard after this period.
• Keep the Humalog mix 25 Kwikpen away from direct sunlight and sources of heat.
• Always check the expiration date before using Humalog mix 25 Kwikpen. Do not use it if it expires.
• Do not let the Humalog mix 25 Kwikpen freeze. If frozen, discard it.

[Note: Follow the storage instructions provided with your Humalog mix 25 Kwikpen and given by your healthcare provider to ensure its potency and safety].

What Medications Interact with Humalog Mix 25 Kwikpen?

Before using the medication, you should tell your doctor about all the medications you currently use or plan to use, including all prescriptions and non-prescription medications, over-the-counter drugs, or herbal and vitamin supplements. This information helps you and your doctor identify and manage potential drug interactions. Here are some of the drugs that Humalog Mix 25 Kwikpen may interact with:

Drug Interactions

• Corticosteroids
• Oral contraceptives (OCs)
• Thyroid replacement therapy
• Danazol
• β2-stimulants
• Oral hypoglycemic agents
• Salicylates
• Sulfa antibiotics
• MAOIs
• SSRIs
• ACE inhibitors
• ARBs
• β-blockers
• Octreotide
• Alcohol

[Note: Always inform your healthcare provider about all medications you’re taking to prevent potential interactions with Huamlog mix 25 Kwikpen and ensure safe and effective treatment].

What Are the Other Humalog Mix 25 Kwikpen Interactions?

While this medication is effective in managing blood glucose levels for many people with diabetes, it’s crucial to understand its potential interactions with various substances and health conditions. Herbs, dietary supplements, certain foods and beverages, and coexisting diseases can all influence the effectiveness and safety of Humalog Mix 25 KwikPen. These interactions may alter blood glucose levels, insulin absorption, or metabolism, potentially leading to hypoglycemia (low blood sugar) or hyperglycemia (high blood sugar). Disease Interactions of Humalog 25 are as follows: 

• Renal/Liver Disease
• Hypokalemia
• Hypoglycemia

What Are the Humalog Mix 25 Kwikpen Alternatives?

Humalog Kwikpen Mix 25 is one of many insulin options for diabetes management. Alternatives include other premixed insulins, separate basal and bolus insulins, and advanced delivery systems like insulin pumps. For some patients with Type 2 diabetes, non-insulin medications may also be considered. The choice of alternative depends on factors such as diabetes type, glucose patterns, lifestyle, and individual treatment goals. These options provide flexibility in tailoring diabetes management to each patient’s unique needs and preferences.

• Novolog Mix 70/30 (insulin aspart protamine/insulin aspart)
• Humulin 70/30 (human insulin isophane/human insulin regular)
• Novolin 70/30 (human insulin isophane/human insulin regular)
• Humalog Mix 50/50 (insulin lispro protamine/insulin lispro)
• Novolog Mix 50/50 (insulin aspart protamine/insulin aspart)
• Lantus (insulin glargine)
• Levemir (insulin detemir)
• Tresiba (insulin degludec)

[Note: Always consult your healthcare provider to determine the most suitable insulin therapy based on your needs, medical history, and treatment goals].

Humalog Mix 25 Kwikpen Cost & Coupons 

Kwikpen Humalog Mix 25 helps manage blood sugar in people with type 1 and type 2 diabetes by combining fast-acting and longer-lasting insulin. While there’s no generic version yet, some savings options are available. Many people turn to pharmacies like Polar Bear Meds to buy Humalog Mix 25 from Canada at a lower cost. You can also use the code WELCOMEPB10 for an extra 10% off your first order. Always check with your doctor before making any changes to your treatment plan.

Frequently Asked Questions

What is the difference between Humalog Kwikpen & Humalog Mix 25 Kwikpen?

Humalog Kwikpen contains insulin lispro, a rapid-acting insulin used to control post-meal spikes. It starts to work within 15 minutes of administration, peaks in about one hour, and continues to work for two to four hours. On the other hand, [Humalog Mix 25 Kwikpen is a combination medicine that contains a mixture of 25% insulin lispro and 75% insulin lispro protamine suspension, which are rapid-acting and intermediate-acting insulins, respectively. The combination of both medications starts working within 15 minutes, peaks in about 2 hours, and its effects can last up to 24 hours.

Is Humalog Mix 25 Kwikpen suitable for people with type 1 diabetes?

Yes, Humalog Mix 25 Kwikpen is suitable for people with type 1 diabetes. It provides a combination of rapid-acting and intermediate-acting insulins, helping to control blood sugar levels throughout the day, including after meals. It’s an important treatment option for individuals with type 1 diabetes, complementing their overall diabetes management plan. However, the specific dosage and usage should be determined by a healthcare provider based on individual needs.

Can I drink alcohol while using Humalog Mix 25 Kwikpen?

Moderate alcohol consumption is generally acceptable while using Humalog Mix 25 Kwikpen. However, alcohol can affect blood sugar levels, potentially leading to hypoglycemia or hyperglycemia. It’s crucial to monitor blood sugar closely and avoid excessive alcohol intake. Consult your healthcare provider for personalized advice regarding alcohol consumption with Humalog Mix 25 Kwikpen.

Can Humalog Mix 25 Kwikpen be used in people with liver problems?

Yes, Humalog Mix 25 Kwikpen can be used in people with liver problems. However, dosage adjustments may be necessary, and close monitoring of blood sugar levels is crucial. It’s important to consult with a healthcare provider who can provide personalized guidance based on individual health conditions and medication requirements.

How long does it take for Humalog Mix 25 Kwikpen to start working?

Humalog Mix 25 Kwikpen starts working relatively quickly after injection. The rapid-acting insulin component begins to take effect within approximately 15 minutes. This makes it effective in addressing post-meal blood sugar spikes and providing timely glycemic control for individuals with diabetes.

Our Guarantee

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