Buy Zytiga Online from Canada (Abiraterone Acetate Tablets)
Abiraterone Acetate
Zytiga
Zytiga (abiraterone acetate) is a medication prescribed for advanced prostate cancer, specifically for metastatic castration-resistant and high-risk castration-sensitive types. The recommended dosage is 1,000 mg daily, taken on an empty stomach with prednisone. Common side effects include fatigue, nausea, and joint pain, while serious side effects may involve heart and liver issues. Zytiga is not suitable for women, particularly during pregnancy. Patients should adhere to their doctor’s instructions regarding dosage and safety precautions and use reliable birth control methods during treatment.
Product Overview
Zytiga (abiraterone acetate) is a medication used in the treatment of prostate cancer, specifically metastatic castration-resistant prostate cancer (mCRPC) and metastatic high-risk castration-sensitive prostate cancer (mHSPC). The main ingredient, abiraterone acetate, works by inhibiting the enzyme CYP17, which is involved in the production of androgens (male hormones) in the testes, adrenal glands, and prostate tumor tissue. By blocking this enzyme, Zytiga reduces the levels of androgens, including testosterone, that can stimulate the growth of prostate cancer cells. This helps to slow the progression of the disease and can be an effective treatment for men with advanced prostate cancer.
Zytiga is available in tablet form with strengths of 250mg and 500mg. The recommended dosage for adults with mCRPC or mHSPC is 1,000 mg taken orally once daily, along with prednisone 5 mg taken orally once or twice daily, depending on the specific condition. Zytiga tablets should be taken on an empty stomach, at least one hour before or two hours after a meal, and swallowed whole with water. It is important for patients to follow their doctor’s instructions for taking Zytiga and prednisone and not to alter or stop taking the medication without consulting their doctor.
Common side effects of Zytiga include fatigue, nausea, joint pain, diarrhea, and edema. Serious side effects can include high blood pressure, low blood potassium levels, fluid retention, irregular heartbeats, and severe liver problems. Patients should inform their doctor if they have any history of heart disease, liver problems, or low potassium levels before taking Zytiga. Additionally, Zytiga is not for use by women, especially during pregnancy or breastfeeding, as it can harm an unborn or breastfeeding baby. Men with female partners of childbearing age should use reliable forms of birth control while taking Zytiga and for at least 3 weeks after stopping treatment. In case of a missed dose or overdose, patients should follow the guidance provided by their healthcare provider. Zytiga should be stored at room temperature, away from moisture and heat, and out of reach of children.
Uses of Zytiga
- Treatment of prostate cancer
How to Use Zytiga?
Dosage
Form: Tablets
Strengths: 250mg, 500mg
Recommended Dosage for Different Patients
Metastatic Castration-Resistant Prostate Cancer (mCRPC):
- Adults: The typical dose is 1,000 mg (four 250 mg tablets or two 500 mg tablets) taken orally once daily, along with prednisone 5 mg taken orally twice daily.
Metastatic High-Risk Castration-Sensitive Prostate Cancer (mHSPC):
- Adults: The usual dose is 1,000 mg (four 250 mg tablets or two 500 mg tablets) taken orally once daily, along with prednisone 5 mg taken orally once daily.
[Note: Remember these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]
How to Take It?
- Take Zytiga tablets once daily as a single dose on an empty stomach.
- Avoid eating food for 2 hours before and 1 hour after taking Zytiga.
- Do not take Zytiga with food, as it can increase absorption and lead to side effects.
- Swallow Zytiga tablets whole with water; do not crush or chew them.
- You will also be prescribed prednisone while taking Zytiga. Follow your doctor’s instructions for taking prednisone.
- Do not alter or stop taking Zytiga or prednisone without consulting your doctor.
[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]
How Does Zytiga Work?
Zytiga (abiraterone acetate) works by inhibiting the enzyme CYP17, which produces androgens (male hormones) in the testes, adrenal glands, and prostate tumor tissue. By blocking this enzyme, Zytiga reduces the levels of androgens, including testosterone, that can stimulate the growth of prostate cancer cells. This helps to slow the progression of the disease and can be an effective treatment for men with metastatic castration-resistant prostate cancer (mCRPC), which is a form of prostate cancer that continues to grow even when testosterone levels are significantly reduced.
Important Safety Information
Side Effects
Common side effects may include:
- Fatigue
- Nausea
- Joint pain
- Diarrhea
- Edema (swelling from fluid buildup in your body)
- Urinary tract infection
- Hematuria (blood in urine)
- Urinary frequency
- Nocturia (excessive urination at night)
- Insomnia
- Constipation
- Dyspepsia (indigestion)
- Vomiting
Serious side effects may include:
- High blood pressure (hypertension)
- Low blood potassium levels (hypokalemia)
- Fluid retention (edema)
- Irregular heartbeats
- Dizziness
- Fast or irregular heartbeats
- Feeling faint or lightheaded
- Headache
- Confusion
- Muscle weakness
- Pain in your legs
- Swelling in your legs or feet
- Adrenal problems
- Severe liver problems, which can lead to death
- Increased risk of bone fracture and death when Zytiga and prednisone or prednisolone is used in combination with a type of radiation called radium Ra 223 dichloride
- Severe low blood sugar (hypoglycemia)
[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]
Warnings
- Do not use Zytiga if you have severe liver disease.
- Before taking Zytiga, inform your doctor if you have low potassium levels, any infection, high blood pressure, congestive heart failure, a history of heart disease, fluid retention, a recent heart attack, or problems with your adrenal or pituitary gland.
- Zytiga is not for use by women, as it can harm an unborn baby or cause birth defects. Pregnant women or those who may become pregnant should avoid handling the tablets.
- While taking Zytiga and for at least 1 week after your treatment ends, use a condom to prevent transferring the medication to your sexual partner if she is pregnant. Use a condom and another form of effective birth control if your partner could become pregnant.
Precautions
- Inform your doctor or pharmacist if you have allergies to abiraterone or any other allergies.
- Discuss your medical history with your healthcare provider, especially if you have had a heart attack, high blood pressure, liver problems, or diabetes.
- Abiraterone may cause QT prolongation, a condition that affects heart rhythm and can lead to serious fast or irregular heartbeat and other symptoms requiring immediate medical attention.
- The risk of QT prolongation may be higher if you have certain heart conditions, a family history of heart problems, or are taking other medications that can cause QT prolongation.
- Low levels of potassium or magnesium in the blood can also increase the risk of QT prolongation. Discuss with your doctor if you are taking diuretics or have conditions like severe sweating, diarrhea, or vomiting.
- Using corticosteroids along with abiraterone for an extended period can affect your body’s response to physical stress. Inform your doctor or dentist if you are using abiraterone before any surgery or emergency treatment or if you experience unusual tiredness or weight loss.
- If you will be taking abiraterone for a long time, carry a warning card or medical ID bracelet indicating your use of this medication.
- Inform your doctor or dentist about all the medications you use, including prescription drugs, nonprescription drugs, and herbal products, before having surgery.
- Older adults may be more sensitive to the side effects of abiraterone, particularly QT prolongation.
- This medication is not for use by women, especially during pregnancy or breastfeeding, as it can harm an unborn or breastfeeding baby.
- Men with female partners of childbearing age should use reliable forms of birth control while taking abiraterone and for at least 3 weeks after stopping treatment. Consult your doctor for more details.
Contraindications
- Pregnancy: Zytiga should not be used in women who are or may become pregnant.
- Severe Liver Impairment: Zytiga should not be used in patients with severe liver impairment (Child-Pugh class C).
- Radium Ra 223: Zytiga should not be combined with radium Ra 223.
- Hypersensitivity: Zytiga should not be used in patients with a known allergy to abiraterone.
Missed Dose
- If you miss a dose of Zytiga, take your regular dose the next day.
- If you miss more than one dose, contact your doctor immediately.
- If you’re unsure whether to take a missed dose or skip it, consult with your doctor or pharmacist.
[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]
Overdose
There is limited experience with Zytiga (abiraterone acetate) overdose. There is no specific antidote for an overdose of Zytiga, and treatment should focus on general supportive measures, including monitoring of cardiac and liver function.
[Note: If you consumed more than recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]
Storage
- Store Zytiga at room temperature, ideally between 68°F to 77°F (20°C to 25°C).
- Keep Zytiga in a tightly closed container.
- Store the medication in a place that is free from moisture and heat.
- Ensure that Zytiga is kept out of reach of children.
- Discard any expired medication or medication that is no longer needed.
[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]
Zytiga Interactions
- CYP3A4 Inducers: Medications such as rifampin, carbamazepine, phenytoin, and phenobarbital can decrease the effectiveness of Zytiga.
- CYP3A4 Inhibitors: Drugs like ketoconazole, itraconazole, clarithromycin, and ritonavir can increase the levels of Zytiga in the blood, potentially leading to more side effects.
- CYP2D6 Substrates: Zytiga may increase the levels of medications metabolized by CYP2D6, such as metoprolol, paroxetine, and desipramine.
- Blood Thinners: There may be an increased risk of bleeding when Zytiga is taken with anticoagulants like warfarin.
- Corticosteroids: Since Zytiga is taken with prednisone, it’s important to monitor for side effects related to corticosteroid use.
- Other Hormonal Therapies: Use caution when combining Zytiga with other hormonal therapies for prostate cancer, as this can affect hormone levels and increase the risk of side effects.
[Note: This isn’t a complete list, and there could be other drugs that interact with (drug name). Make sure to tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]
Zytiga Alternatives
- Xtandi (enzalutamide)
- Erleada (apalutamide)
- Nubeqa (darolutamide)
- Casodex (bicalutamide)
- Faslodex (fulvestrant)
- Lynparza (olaparib)
- Rubraca (rucaparib)
[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]
Frequently Asked Questions
Why is it necessary to take Zytiga (abiraterone) without food?
Taking Zytiga (abiraterone) on an empty stomach is crucial because food can significantly increase the absorption of the medication in your body. Consuming it with food may lead to excessive absorption, resulting in an increased risk of side effects from Zytiga (abiraterone).
Can (Zytiga) impact my fertility?
Abiraterone (Zytiga) may potentially affect your fertility. Although there is limited research in humans, animal studies suggest that abiraterone (Zytiga) can reduce sperm production and cause sperm damage. If you are concerned about your fertility, it’s important to discuss this with your healthcare provider.
Can Zytiga influence my testosterone levels?
Yes, Zytiga is designed to slow or halt the progression of prostate cancer by reducing the levels of testosterone and other male hormones in your body. It achieves this by inhibiting the production of other steroids that contribute to the formation of testosterone and also by decreasing the levels of another key male hormone, dihydrotestosterone.
Is (Zytiga) considered chemotherapy?
No, abiraterone (Zytiga) is not classified as chemotherapy. Chemotherapy typically involves drugs that kill cancer cells directly. Abiraterone, on the other hand, is a type of hormonal therapy known as an antiandrogen. It operates by reducing the production of testosterone in your body, which is a hormone that most prostate cancer cells rely on for growth and spread. By decreasing testosterone levels, abiraterone (Zytiga) limits the “fuel” available for cancer cells to proliferate or metastasize.
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