Apixaban

Eliquis

Eliquis (Apixaban) is a brand-name prescription approved by the FDA to prevent and treat dangerous blood clots in various conditions, such as reducing the risk of stroke in individuals with nonvalvular atrial fibrillation (NVAF). It is also prescribed for the treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE), as well as to prevent these conditions after knee or hip replacement surgery. It is an oral anticoagulant and works by blocking the activity of a clotting substance called factor Xa in the blood. Available in 2.5mg and 5mg tablets, its dosage varies based on the condition being treated. Patients are advised to buy eliquis online only with a doctor’s prescription and follow their instructions closely to minimize risks, including serious bleeding. 

Product Overview

Eliquis, also known as Apixaban, is a medication used to prevent and treat blood clots, significantly reducing the risk of strokes in people with a heart condition called nonvalvular atrial fibrillation. This condition causes an irregular heartbeat, which can lead to dangerous clots forming in the heart and traveling to other parts of the body. Eliquis effectively treats deep vein thrombosis (DVT), which is a clot in the legs, and pulmonary embolism (PE), where clots move to the lungs. It’s also used to prevent these clots from happening again after initial treatment and to prevent clot formation after knee or hip replacement surgery.

Taking Eliquis correctly, as prescribed by your doctor, is crucial. It works by blocking a specific protein in the blood that helps it to clot, known as factor Xa. This reduces the likelihood of clots forming. While Eliquis is an important medication for many, it can cause side effects. These range from minor issues like nausea and easy bruising to more serious problems such as significant bleeding or allergic reactions.

It’s important not to take Eliquis if you have severe kidney or liver issues, are currently bleeding, or are taking other blood-thinning medications. Also, it’s not recommended for use during breastfeeding. Unlike some other blood thinners, you don’t need regular blood tests to monitor Eliquis’s effectiveness. For safety and the best outcomes, always discuss your medical history and any other medications you take with your healthcare provider before starting or even when you Eliquis 5 mg buy online. This ensures that the medicine is a safe choice for you and helps avoid potential complications.

What Are the Uses of Eliquis?

Eliquis is used for several purposes:

• To lower the chance of stroke and blood clots in people with a type of irregular heartbeat known as nonvalvular atrial fibrillation (NVAF).
• For treating deep vein thrombosis (DVT), a condition usually happens in the legs (where blood clots form in the deep veins).
• For treating pulmonary embolism (PE), which occurs when a blood clot travels to the lungs.
• To decrease the risk of deep vein thrombosis and pulmonary embolism happening again after initial treatment.
• As a preventive measure against deep vein thrombosis, which can lead to pulmonary embolism, in patients who have had hip replacement surgery.
• For preventing deep vein thrombosis, which can lead to pulmonary embolism, in patients who have undergone knee replacement surgery.

What Are the Forms & Strengths of Eliquis?

Dosage

It comes in the form of an oral tablet and has two strengths: 

• 2.5mg 
• 5mg 

What Are the Recommended Eliquis Doses for Different Patients? 

Reducing the risk of systemic/stroke embolism in NVAF

• 5 mg two times daily
• For patients with NVAF, a dosage of 2.5 mg two times a day is recommended for those who have at least 2 of the following characteristics:
  • age ≥80 years
  • body weight ≤60 kg
  • serum creatinine ≥1.5 mg/dL

Treatment of DVT/PE

• 10 mg two times daily for the first seven days
•  After seven days- transition to 5 mg two times daily

Reducing the risk of recurrent PE/DVT after initial therapy

• 2.5 mg two times daily at least after six months of treatment for PE or DVT

Prophylaxis of DVT, which can lead to PE after knee or hip replacement surgery

• 2.5 mg twice daily for 12 days, starting 12 to 24 hours after knee replacement surgery
• 2.5 mg twice daily for 35 days, starting 12 to 24 hours after hip replacement surgery

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

What Is the Proper Way to Take Eliquis?

When you buy Eliquis online, you can take this medication in the following ways: 

• Before you start using Eliquis, you should carefully read and follow the instructions for use given in the patient information leaflet & medication guide provided by your pharmacist and healthcare provider. If you have any doubts regarding medication usage or if you do not understand any part of the leaflet, you should ask your physician or healthcare provider. 
• The medication dosage is based on the medical condition being treated, age, weight, other medications you may be taking, and your body’s response to the treatment. 
• Take the medicine twice daily by mouth, with or without food, exactly as your doctor has instructed. Don’t use more than suggested, don’t use it more frequently, and don’t use it longer than your doctor recommended.
• If you’re about to run out of Eliquis, contact your doctor or pharmacist in advance. Avoid running out of medicine.
• If swallowing whole tablets is difficult for you, there are other options. The tablets can be crushed and mixed with D5W (IV solution), water, apple juice, or applesauce. 
• Alternatively, if you’re using a nasogastric tube (NGT), which is a tube that goes through the nose to the stomach, you can mix the crushed tablets with 60 mL of water or D5W and administer it that way.
• You should not discontinue using Eliquis without consulting your doctor, as it can lead to undesirable side effects. 
• To get the most benefit from your medication, you should maintain consistency in dosage and take it around the same time every day. 
• Tell your doctor if your condition does not get better or if it worsens. 
• Do not share your medications with other people, even if they have the same condition as you. 
• Keep Eliquis at room temperature in its original packaging, away from light, moisture, and heat. 

[Note: Carefully follow the instructions and consult your doctor if you have any questions.]

How Does Eliquis Work?

Eliquis is an anticoagulant that works by binding to a specific protein involved in blood clotting, known as factor Xa. The liver produces this protein and plays a crucial role in the formation of blood clots. By inhibiting the activity of factor Xa, Eliquis effectively reduces the blood’s capacity to form clots. This further prevents the formation of harmful clots in the blood vessels.

Important Safety Information

What Are the Side Effects of Eliquis?

Mild or common side effects of Eliquis include:

• Mild Bleeding: Users of Eliquis may experience minor bleeding incidents such as nosebleeds, bleeding gums, or small red spots under the skin, known as petechiae.
• Anemia: Eliquis may cause anemia, which can manifest as unusual fatigue, paleness, or shortness of breath due to a decreased level of red blood cells.
• Easy Bruising: Individuals taking Eliquis might find that they bruise more easily than usual, which is a result of the blood’s reduced clotting ability.
• Nausea: Some users of Eliquis report transient nausea, although it is typically mild and temporary.

Usually, these side effects should lessen or disappear within a few days to two weeks. However, if they worsen or persist, you should consult your doctor or pharmacist.

Serious side effects of Eliquis include:

• Allergic Reaction: Eliquis can cause severe allergic reactions, evidenced by hives, swelling of the face, lips, tongue, or throat, and difficulty breathing. This requires immediate medical intervention.
• Increased Risk for Blood Clots: Discontinuing Eliquis without medical advice may significantly increase the risk of developing blood clots. Always consult a healthcare professional before stopping or altering your dosage.
• Serious Bleeding: Eliquis may lead to serious bleeding events, such as severe gastrointestinal bleeding or cerebral hemorrhages. Symptoms to watch for include prolonged bleeding from cuts, increased menstrual flow, unusually severe bruising, coughing up blood, or any persistent bleeding.
• Blood Clots in the Spine from Spinal Procedures: This rare but critical side effect of Eliquis can occur after spinal taps or epidural anesthesia, which may lead to long-term or permanent paralysis.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

What Are the Eliquis Warnings?

While it is an effective anticoagulant, it is important to be aware of the warnings associated with its use. If you’re considering to buy Eliquis online, it’s crucial to understand these warnings to ensure safe and effective use.

Stopping Eliquis Too Soon Increases Clotting Risk: If you stop taking Eliquis too soon, it raises the risk of blood clot-related issues. Stopping any oral anticoagulant, like Eliquis, prematurely can lead to this increased risk. If you need to stop taking Eliquis for reasons other than severe bleeding or finishing your prescribed course of treatment, it’s important to think about switching to a different blood thinner.

Risk of Spinal or Epidural Blood Clots: People taking Eliquis who have spinal anesthesia or a spinal tap can develop blood clots in the spinal area. These clots can cause long-term or permanent paralysis. Be aware of these risks when planning spinal procedures. Factors that raise the risk of these clots include:

• Having a catheter placed in the epidural space
• Using other medications that affect blood clotting, such as NSAIDs, platelet inhibitors, or other blood thinners
• A history of difficult or multiple spinal taps or punctures
• A history of spinal deformity or surgery
• The best timing between taking Eliquis and having a spinal procedure is not clear

[Note for Doctors: Regularly check patients for any signs of nerve or spinal problems. If there are signs of nerve issues, immediate medical attention is needed. Weigh the pros and cons carefully before doing any spinal procedures in patients who are taking or will take blood thinners.]

What Are the Eliquis Precautions?

When you consider Eliquis 5 mg buy online, there are several important precautions to consider to ensure its safe and effective use. If you are considering the option to buy apixaban online, it’s crucial to be aware of these precautions:

Allergies and Inactive Ingredients: Before starting Apixaban, let your doctor or pharmacist know if you are allergic to it or if you have any allergies. Sometimes, this medication contains ingredients that might trigger allergies or other problems. You can discuss this with your pharmacist for more information.

Your Medical History Matters: It’s important to share your medical history with your doctor or pharmacist before using this medication. Especially if you have:

• Liver or kidney disease
• Previous bleeding problems, like bleeding in the stomach, intestines, or brain
• Blood disorders, such as anemia, hemophilia, or thrombocytopenia
• A recent major injury or surgery
• History of stroke
• A clotting disorder called antiphospholipid syndrome
• A tendency to experience frequent falls or injuries

Before Surgery or Medical/Dental Procedures: If you’re planning to have surgery or any medical or dental procedures, especially those involving spinal puncture or spinal/epidural anesthesia, make sure to inform your doctor or dentist that you are taking Apixaban. They might advise you to temporarily stop taking the medication. It’s essential to follow their instructions regarding when to stop and restart Apixaban.

Alcohol and Stomach Bleeding: Eliquis (Apixaban) can lead to stomach bleeding, and consuming alcohol daily while using this medicine can increase this risk. Therefore, it’s advisable to limit your alcohol intake. If you have questions about how much alcohol you can safely drink, consult your doctor or pharmacist.

Risk of Heavy Bleeding: This medication may increase the likelihood of heavy bleeding. To reduce the chances of getting cut, bruised, or injured:

• Be cautious when handling sharp objects like razors and nail cutters.
• Avoid engaging in activities like contact sports.
• Opt for an electric razor when shaving.
• Use a soft toothbrush when brushing your teeth.
• If you happen to fall or injure yourself, especially if you hit your head, contact your doctor promptly. They may need to examine you to ensure your safety.

What Are Other Important Eliquis Precautions?

When considering Eliquis 5 mg buy online, it is crucial to be aware of several other important precautions to ensure an effective treatment. Here are key precautions to keep in mind:

Pregnant and Breastfeeding Women: Current information about the use of Eliquis during pregnancy is not enough to determine its potential risks, including birth defects, miscarriage, or negative effects on the baby’s development. Using this medication might raise the chances of bleeding in both the mother and infant during pregnancy and childbirth. Breastfeeding is not recommended with the treatment of Eliquis.

Women Planning for Pregnancy: Women who can have children and need blood-thinning medication should talk with their doctor about planning for pregnancy. It’s important to evaluate the risk of serious bleeding in the uterus, which might need surgical treatment by a gynecologist, especially when using oral anticoagulants like Eliquis. This is particularly important for women who experience unusual bleeding from the uterus.

Labor or Delivery: During childbirth, women who are taking Eliquis and also receiving an epidural or spinal anesthesia should be aware of the risk of bleeding complications, such as epidural or spinal hematomas. It may be advisable to switch to a different anticoagulant that has a shorter duration of action as the time of delivery gets closer.

What Are Eliquis Contraindications?

Eliquis is contraindicated for use in patients who have:

• Active pathological bleeding
• Severe hypersensitivity reaction (such as anaphylactic reactions)

What Happens If You Miss a Dose of Eliquis?

To get the most benefit from your medication, you should set a time that is most convenient for you and take it around the same time everyday. If you miss a dose of Eliquis, take it immediately. But if it’s nearly time for your next dose, just skip the one you missed and continue with your normal schedule. Remember, don’t take two doses at once to compensate for a missed dose. You should set a reminder on your phone to prevent missing doses further. Medication reminders work best for this purpose. 

[Note: Always adhere to the instructions given by your doctor to use your medications safely and effectively.]

What Happens If You Take Too Much Eliquis?

Call your doctor immediately if you’ve taken too much Eliquis or notice any of these symptoms of Eliquis overdose:

• Vomiting blood
• Coughing up blood
• Having blood in your stool or urine
• Non-stop bleeding, such as from a wound

If you experience severe side effects such as seizures, difficulty breathing, or passing out, you can also head to the nearest emergency room or call your local poison control centre.

[Note: If you consumed more than recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]

How Do You Store Eliquis?

When you consider apixaban 5 mg buy online, proper storage of this medication ensures its effectiveness for usage purposes. Follow these guidelines to store your medication correctly:

• Store this medicine at room temperature in a closed container.
• Keep it away from moisture, heat, and direct light. 
• Do not freeze it.
• Keep it out of the reach of children.
• Dispose of the medicine if it’s outdated or no longer in need. 
• It is important to dispose of unwanted and out-of-date medications in a way that keeps them out of the reach of kids, pets, and other people. 

[Note: Consult your doctor for any questions you may have regarding storing or disposing of this medication.]

What Are the Eliquis Interactions?

When Eliquis (Apixaban) is used with certain other drugs, there can be an increased risk of bleeding. Before using Eliquis you should tell your doctor about all the medications you are using or plan to use including all prescription, non-prescription medicines, over-the-counter drugs, and herbal or vitamin supplements. This information will help you and your doctor determine the potential drug interactions of Eliquis and also helps in preventing and managing them. These interactions are important to understand and manage:

Combined P-gp and Strong CYP3A4 Inhibitors

Some medications can increase the level of Apixaban in the body, raising the risk of bleeding. These include drugs that inhibit both P-glycoprotein (P-gp) and cytochrome P450 3A4 (CYP3A4). Examples are ketoconazole, itraconazole, and ritonavir. If a patient takes 5 mg or 10 mg of Eliquis twice a day, the dose should be cut in half when any of these inhibitors are used simultaneously. However, if a patient is already on a lower dose of Eliquis (2.5 mg twice daily), it’s best to avoid these inhibitors altogether. An exception is clarithromycin; despite being a combined P-gp and CYP3A4 inhibitor, it doesn’t require a dose adjustment when used with Eliquis.

Combined P-gp and Strong CYP3A4 Inducers

There are certain drugs that lower the effectiveness of Apixaban by reducing its level in the body. These are known as combined P-gp and strong CYP3A4 inducers, such as rifampin, carbamazepine, phenytoin, and St. John’s wort. It’s advised to avoid using these drugs alongside Eliquis to maintain its efficacy.

Anticoagulants and Antiplatelet Agents

The use of Eliquis with other drugs that affect blood clotting (like antiplatelet agents, fibrinolytics, heparin, aspirin, and NSAIDs) also increases the risk of bleeding. A clinical trial (APPRAISE-2) involving high-risk patients after a heart attack showed a higher rate of bleeding in those treated with Apixaban and aspirin or a combination of aspirin and clopidogrel compared to those who received a placebo.

What Are the Other Interactions of Eliquis?

When you buy apixaban online, it’s essential to discuss all the supplements, herbs, and vitamins you are taking with your doctor and pharmacist. This precaution helps avoid possible interactions and ensures the safe use of Eliquis. If you have concerns or questions about potential interactions, your doctor or pharmacist can provide personalized advice.

• Eliquis Interactions with Herbs: Eliquis can interact with the herb St. John’s wort, making the medication less effective. Due to this risk, it’s generally recommended not to take St. John’s wort while on Eliquis. If you currently take St. John’s wort and wish to continue, consult your doctor. They may suggest an alternative medication that doesn’t interact with St. John’s wort.
• Eliquis and Vitamins: Currently, there are no reported interactions between Eliquis and vitamins. However, this does not rule out the possibility of future discoveries of such interactions. It’s important to check with your doctor or pharmacist before adding any new vitamins to your regimen while taking Eliquis.
• Eliquis Interact with Food: Foods like grapefruit can interact with Eliquis, increasing the risk of side effects, particularly bleeding. It’s advisable to avoid consuming grapefruit and grapefruit products while on Eliquis. If you consume grapefruit regularly and wish to continue, your doctor may need to adjust your Eliquis dosage.
• Eliquis Interact with Vaccines: Eliquis is not known to interact with any vaccines. However, always inform your doctor or pharmacist about all medications you are taking before receiving a vaccine to ensure it is safe.
• Eliquis Interact with Lab Tests: Eliquis does not have known interactions with lab tests. However, if you have concerns about potential interactions between your medications and lab tests, it’s best to discuss these with your doctor.

[Note: This isn’t a complete list, and there could be other drugs that interact with Eliquis. Make sure to tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are Eliquis Alternatives?

There are several alternative medications to Eliquis, each with its own benefits and considerations. People look for alternatives to Eliquis when it does not provide desired results or cause unwanted side effects. There are many effective alternatives to Eliquis available in the market. However, you should consult an expert healthcare practitioner before you change or start a new medication. These alternatives are as follows:

• Pradaxa (dabigatran)
• Xarelto (rivaroxaban)
• Savaysa (edoxaban)
• Coumadin or Jantoven (warfarin)
• Heparin
• Lovenox (enoxaparin)
• Acova (argatroban)
• Fragmin (dalteparin)
• Iprivask (desirudin)
• Arixtra (fondaparinux)
• Angiomax (bivalirudin)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Quick Tips

1. How to manage side effects of Eliquis
2. Foods to avoid on Eliquis
3. What happens if you drink alcohol while on blood thinners?
4. Benefits of using Eliquis 2.5 mg
5. What happens if you use probiotics with Eliquis

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Frequently Asked Questions

Is Eliquis an anticoagulant or antiplatelet?

Eliquis (apixaban) is an anticoagulant, not an antiplatelet. It functions by obstructing a specific protein involved in blood clotting, helping to prevent the formation of dangerous clots. Eliquis is often prescribed for conditions like deep vein thrombosis, atrial fibrillation, or pulmonary embolism to decrease the risk of blood clots or stroke. It doesn’t affect platelets directly, unlike antiplatelet drugs like aspirin. 

Can I cut the Eliquis 2.5mg Tablet?

If you find it hard to swallow the whole Eliquis 2.5mg tablet, you can crush the tablet and mix it with water, 5% dextrose in water, apple juice, or apple puree. Just make sure to crush the medicine right before you take it. Talk to your doctor if you’re still unsure how to take and buy apixaban online.

What’s the Eliquis dosage for older adults?

The dosage of Eliquis for older adults can vary depending on the reason for its use. In some cases, the dosage is the same for older adults and younger individuals. This applies when Eliquis is prescribed to treat or prevent conditions like deep vein thrombosis (DVT) or pulmonary embolism (PE).

However, if Eliquis is prescribed to prevent stroke or blood clots related to atrial fibrillation (A-fib) in older adults, the doctor may recommend a lower dosage under certain circumstances. Specifically, a lower dosage may be prescribed if at least two of the following factors apply to the older adult:

• They are 80 years of age or older.
• They weigh 60 kilograms (about 132 pounds) or less.
• They have a kidney problem.

Consult your doctor or pharmacist, and they will determine the most suitable dosage for your specific needs.

How long does Eliquis stay in your system?

Eliquis typically remains in your body for approximately 2 to 3 days after discontinuing its use. This means that if you have a major surgery planned, especially one that carries a higher risk of bleeding, it’s advisable to stop taking Eliquis at least 48 hours before the procedure. If your surgery has a lower risk of bleeding, you should pause Eliquis at least 24 hours in advance. Discuss with your healthcare provider about temporarily discontinuing your treatment if you have a scheduled surgery and if you want to apixaban 5 mg buy online.

Are there any foods I should avoid while using Eliquis?

During your treatment with Eliquis, avoid consuming grapefruit and its juice. This is because it is processed in your liver by a protein called CYP3A4. Eating grapefruit or drinking grapefruit juice can interfere with how this protein works and make it less effective. As a result, the level of Eliquis in your body might become too high, increasing the risk of serious side effects. If you’re unsure or have questions about eating grapefruit or other foods while on Eliquis, it’s best to consult your doctor.

Does Eliquis 2.5 mg tablets cause joint pain?

Yes, Eliquis can lead to joint pain, particularly in patients who start taking it following major surgeries, such as operations on the hip or knee. If you notice any joint pain or swelling after undergoing surgery, it’s important to consult your doctor promptly. These symptoms could be a sign of a more serious condition.

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