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Product Details

Eliquis (Apixaban)

Eliquis (Apixaban)

Eliquis (apixaban) is a prescription-only anticoagulant (blood thinner) used to prevent and treat serious, potentially life-threatening blood clots. It reduces the ability of blood to form clots, helping lower the risk of stroke in atrial fibrillation and preventing deep vein thrombosis (DVT) or pulmonary embolism (PE).

Eliquis tablets are intended for long-term or short-term use, depending on the condition being treated. Always take Eliquis under the guidance of a licensed healthcare provider. For patients seeking cost savings, licensed pharmacies in Canada may offer competitive pricing and discreet delivery options, helping make treatment more affordable without compromising quality.

Eliquis Quick Facts

Generic NameApixaban
Brand NameEliquis
Drug ClassFactor Xa inhibitor (oral anticoagulant)
FDA First Approval2012
Prescription RequiredYes, Eliquis is prescription‑only (Rx‑only)
Dosage FormsOral tablets
Strengths2.5 mg, 5 mg
FDA‑Approved Uses (Indications)• Reduce risk of stroke & systemic embolism in non‑valvular atrial fibrillation
• Treatment of DVT (deep vein thrombosis)
• Treatment of PE (pulmonary embolism)
• Reduce risk of recurrent DVT & PE after initial therapy
• DVT prevention after knee or hip replacement surgery
Eliquis Boxed Warning (FDA)• Spinal/Epidural hematoma risk with neuraxial anesthesia or spinal puncture
• Premature discontinuation raises the risk of thrombotic events
Common Side Effects (FDA‑listed)• Bleeding (most common)
• Bruising
• Anemia
Serious Risks• Major bleeding
• Spinal/epidural hematoma
Contraindications• Active pathological bleeding
• Severe hypersensitivity to apixaban
Storage• Store these tablets at 20°C to 25°C (68°F-77°F)
• Excursions allowed: 15°C to 30°C (59°F-86°F)
• Keep in original container; protect from moisture
Administration RouteOral tablet
ManufacturerBristol‑Myers Squibb / Pfizer

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What Is Eliquis Used For?

What Is Eliquis Used For?

“Healthcare providers prescribe Eliquis for its FDA-approved uses:

  • Non‑valvular atrial fibrillation (AFib): Reduce the risk of stroke and systemic embolism
  • Deep vein thrombosis (DVT) treatment: Treats blood clots in the deep veins, typically in the legs.
  • Pulmonary embolism (PE) treatment: Treats blood clots that travel to the lungs.
  • Prevention of recurrent DVT and PE: Lowers the risk of new clots after initial treatment.
  • DVT prevention after knee or hip replacement surgery: Reduces the chance of blood clots forming after orthopedic surgery.
Eliquis Dosage Guide

Eliquis Dosage Guide

Below are general Eliquis dosing guidelines. Always follow your healthcare provider’s instructions, as Eliquis doses may be adjusted based on kidney function, age, body weight, or other medications.

ConditionTypical Starting DoseMaintenance DoseDuration
Non‑valvular atrial fibrillation (AFib)5 mg orally twice daily5 mg twice dailyOngoing (long‑term)
AFib (dose adjustment)2.5 mg twice dailyUse if patient has ≥2 of: age ≥80 yrs, weight ≤60 kg, or serum creatinine ≥1.5 mg/dLOngoing
DVT or PE treatment10 mg twice daily for the first 7 daysThen 5 mg twice dailyAt least 6 months (as directed)
Prevention of recurrent DVT/PE2.5 mg orally twice daily2.5 mg twice dailyLong‑term (after ≥6 months of treatment)
DVT prevention after hip replacement surgery2.5 mg orally twice daily2.5 mg twice daily35 days (start 12-24 hours post‑surgery)
DVT prevention after knee replacement surgery2.5 mg orally twice daily2.5 mg twice daily12 days (start 12-24 hours post‑surgery)

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What Is the Correct Way to Take Eliquis Tablets?

What Is the Correct Way to Take Eliquis Tablets?

  • Tablets are taken orally, usually twice daily, with or without food.
  • The tablets should be swallowed whole, but they may be crushed and mixed with water, applesauce, or apple juice if needed or directed. This is for people who cannot swallow a whole tablet. Follow the prescribing information.
  • Take Eliquis at the same time each day to keep steady blood levels.
How Does Eliquis Work?

How Does Eliquis Work?

Eliquis works by blocking Factor Xa, a protein the body uses to form blood clots. When Factor Xa is blocked, the blood is less likely to clot too easily. This helps prevent dangerous clots that can cause a stroke, deep vein thrombosis (DVT), or pulmonary embolism (PE).

By targeting this specific step in the clotting process, Eliquis helps maintain blood flow through the blood vessels. It provides a stable anticoagulant effect without the need for routine blood tests in most people.

What Are the Side Effects of Eliquis?

What Are the Side Effects of Eliquis?

Like all medications, Eliquis can cause side effects, although not everyone experiences them.

Most Common Side Effects of Eliquis

  • Bleeding (nosebleeds, gum bleeding, easy bruising)
  • Anemia (low red blood cell count)
  • Nausea
  • Mild stomach discomfort

Eliquis Serious Side Effects (Rare)

  • Major bleeding (internal bleeding, gastrointestinal bleeding, intracranial hemorrhage)
  • Spinal/epidural hematoma (risk increases with spinal puncture or epidural anesthesia; may cause paralysis)
  • Stroke or blood clot risk if Eliquis is stopped suddenly (FDA boxed warning)
  • Severe allergic reactions (rash, itching, swelling, difficulty breathing, rare but serious)
  • Liver problems (rare cases of abnormal liver function tests or injury)
FDA Eliquis Warning

FDA Eliquis Warning

Eliquis Boxed Warning:

  • Premature discontinuation of Eliquis increases the risk of blood clots. Stopping Eliquis without proper medical guidance can raise the risk of stroke or other serious clotting events.
  • Spinal or epidural blood clots (hematomas) may occur in people receiving spinal procedures (such as epidural anesthesia or spinal puncture) while taking Eliquis. These clots may cause long-term or permanent paralysis.

Important Points:

  • Do not stop taking Eliquis without talking to your healthcare provider.
  • Seek immediate medical attention if you develop numbness, back pain, tingling, muscle weakness, or loss of bladder or bowel control after a spinal procedure.
Important Safety Information About Eliquis

Important Safety Information About Eliquis

  • If you miss a dose of Eliquis (apixaban), take it as soon as you remember unless your next dose is due soon. If more than 6 hours have passed, skip the missed dose and take your next dose at the regular time.
  • Do not take a double dose to make up for a missed one.
  • Taking too much Eliquis can increase the risk of serious or life-threatening bleeding. Seek medical help or call the Poison Control at 1-800-222-1222 if an Eliquis overdose is suspected.
  • Stop taking Eliquis and contact your doctor right away if you have heavy bleeding or notice blood in your urine or stools, black stools, coughing up blood, or vomiting blood.

Who Should Not Take Eliquis

  • People with active pathological bleeding.
  • Those with a severe allergic reaction to apixaban or any ingredient in Eliquis.
  • Patients with certain artificial heart valves (not FDA‑approved for this use).
  • Use caution in severe liver disease.

What Precautions Should Be Taken While Taking Eliquis?

  • Provide a complete list of medications to your physician to avoid adverse interactions.
  • Inform your provider if you have kidney or liver problems.
  • Tell your healthcare provider before surgery or dental procedures that you are taking Eliquis tablets.
  • The risk of bleeding may be higher in older adults, so careful monitoring and, in some cases, dose adjustments may be needed.
  • Maintain regular medical check‑ups to monitor safety.

What to Avoid While on Eliquis?

  • Excessive alcohol intake, which can increase the risk of bleeding.
  • Avoid stopping Eliquis abruptly without medical advice, as this can increase the risk of thrombosis.
  • Combining Eliquis with other blood thinners unless directed by a doctor.
  • Activities with high risk of injury or bleeding (contact sports, unsafe falls).
What Medications Should Not Be Taken with Eliquis?

What Medications Should Not Be Taken with Eliquis?

Eliquis (apixaban) should not be taken with certain medications that strongly affect its metabolism or increase bleeding risk.

Drug ClassDrug Examples
Strong CYP3A4/P-gp inhibitorsKetoconazole, Itraconazole, Ritonavir, Clarithromycin
Strong CYP3A4/P-gp inducersRifampin, Carbamazepine, Phenytoin, St. John’s Wort
Other anticoagulantsHeparin, Enoxaparin, Dabigatran, Rivaroxaban
Antiplatelet agentsAspirin, Clopidogrel, Prasugrel, Ticagrelor
NSAIDsIbuprofen, Naproxen

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What Are the Alternatives to Eliquis?

What Are the Alternatives to Eliquis?

Here are some Eliquis alternatives you may consider consulting with your doctor:

MedicationDrug Class
Eliquis (apixaban)Factor Xa inhibitor
Xarelto (rivaroxaban)Factor Xa inhibitor
Pradaxa (dabigatran)Direct thrombin inhibitor
Savaysa (edoxaban)Factor Xa inhibitor
WarfarinVitamin K antagonist
Heparin/LMWHInjectable anticoagulant

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Eliquis vs Other Blood Thinners

Below is an Eliquis head-to-head comparison of mechanisms, dosing, monitoring, renal use, and bleeding risk:

AttributeEliquis (Apixaban)Pradaxa (Dabigatran)Xarelto (Rivaroxaban)Warfarin
MechanismFactor Xa inhibitorDirect thrombin (IIa) inhibitorFactor Xa inhibitorVitamin K antagonist (reduces II, VII, IX, X)
Typical dosing (NVAF)5 mg BID; 2.5 mg BID if dose-reduction criteria met150 mg BID; dose adjust in renal impairment20 mg QD with food; dose adjust in renal impairmentIndividualized dosing; INR 2–3
Routine monitoringNot required; monitor for bleedingNot required; monitor for bleedingNot required; monitor for bleedingRequires regular INR checks and dose adjustments
Renal considerationsLess renal clearance; dose reduction in select patientsMostly renally cleared; sensitive to kidney functionDose adjustment needed; higher renal clearance than EliquisNot renally cleared; often used in severe renal failure or dialysis
Food/diet interactionsNo restrictionsCapsules must be swallowed whole15-20 mg must be taken with foodVitamin K intake affects INR; a consistent diet is required
Drug interactionsAvoid strong CYP3A4/P-gp inhibitors or inducersAffected by P-gp inhibitors/inducersAvoid strong CYP3A4/P-gp inhibitors or inducersMany interactions via CYP2C9, 1A2, 3A4; multiple prescription/OTC conflicts
Bleeding profileMay have lower GI bleeding risk than Pradaxa and Xarelto; lower intracranial bleeding vs WarfarinHigher GI bleeding riskHigher GI bleeding riskHigher risk of intracranial bleeding
AdministrationTablets can be crushed or suspendedCapsules must not be opened or crushedHigh-dose tablets with foodMultiple strengths; frequent dose changes based on INR
Use notesOften used in older adults, CKD, or high bleeding riskMay be avoided in severe renal impairmentOnce-daily convenience; bleeding risk is higher than EliquisOften chosen for cost, or severe renal failure; requires monitoring

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Eliquis FAQs

Eliquis FAQs

Our Guarantee for Buying Eliquis from Polar Bear Meds

Our Guarantee for Buying Eliquis from Polar Bear Meds

Ordering Eliquis online through a licensed Canadian pharmacy gives you safe, reliable access to your medication at potentially lower costs. Many patients pay up to 90% less than at U.S. pharmacies. New customers may use the Eliquis coupon code WELCOMEPB10 to receive an additional 10% off their first order. To give customers added confidence, we also offer a price-match guarantee, helping ensure you receive the best available price when ordering from Polar Bear Meds.

Shipping Eliquis from Canada to the U.S.

  • Most deliveries arrive within 3-5 business days after your prescription is verified.
  • You’ll receive tracking information so you can track your order every step of the way.
  • Customer support (1-888-779-2193) is available to answer any questions about shipping, delivery, or order status.

How do I submit my Eliquis prescription?

You can submit your Eliquis prescription easily through your online account after placing your order. A scanned copy or a clear photo of the prescription can be uploaded directly to the website. Additionally, prescriptions may also be sent by email or fax (1-888-804-1287). If a prescription is missing or incomplete, our support team will contact you to help complete the process.

Important Notice

Important Notice

This information is for educational purposes only and does not replace any professional medical advice, diagnosis, or treatment. Always consult a licensed healthcare expert before starting, stopping, or changing Eliquis dosages. Individual results, dosing, and Eliquis side effects may vary.

Dr. Jackson Miller

Medically Reviewed by Dr. Jackson Miller (M.D)

Dr. Jackson Miller is a board-certified medicine physician & hospitalist. He is a healthcare professional with a strong background in patient care. With years of experience and a patient-first approach, he believes the foundation of good health is a patient who feels informed and empowered. He contributes to medical content review, drawing on his background in clinical practice and patient education. He focuses on presenting health information in a clear, accurate, and accessible way to help readers make informed decisions. His work emphasizes clarity, evidence-based guidance, and understandable explanations of medical topics.

Find Dr. Jackson Miller on:LinkedIn

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