Pramipexole 

Pramipexole

Pramipexole is an FDA-approved medication used to treat Parkinson’s disease and other medical conditions, such as restless legs syndrome. Doctors usually prescribe this medication to improve the patient’s ability to move and reduce shakiness, slowed movement, stiffness, and unsteadiness. Pramipexole can be used alone or in combination with other medications. While it is suitable for adult use, its dosage may vary depending on each patient’s medical condition and the dosage form they take. It is important to note that Parkinson’s and RLS are two different disorders. Having one of these disorders will not cause the other condition. Moreover, patients are advised to follow their dosage recommendations exactly as a medical professional prescribes.        

Product Overview

Pramipexole is a prescription medication primarily used to treat symptoms of Parkinson’s disease and Restless Legs Syndrome (RLS). The active ingredient, pramipexole dihydrochloride, is a dopamine agonist that stimulates the brain’s dopamine receptors, helping to improve movement and control. This medication is FDA-approved and is known for its effectiveness in managing the symptoms of these neurological conditions.

Pramipexole is available in extended and immediate-release tablet form, with strengths ranging from 0.125 mg to 1.5 mg. The dosage & frequency depend on the condition being treated and the patient’s response to the medication. Typically, it is taken orally with or without food, as prescribed by a healthcare provider. It is important to stick to the recommended dosage schedule to achieve optimal results. Adults can use Pramipexole, and its effectiveness is based on its ability to mimic the action of dopamine, thereby improving motor function and reducing the discomfort associated with RLS.

Common side effects of Pramipexole include nausea, dizziness, drowsiness, and insomnia. It is advised to take precautions, such as avoiding activities that require alertness, like driving, until the body adjusts to the medication. In case of a missed dose, take it as soon as remembered unless it is close to the time for the next dose. Do not double up to make up for the missed dose. In case of a Pramipexole overdose, get immediate medical attention.

What Are the Uses of Pramipexole?

This medication is used for:

• Controlling the symptoms of Parkinson’s disease, including muscle control, balance, and movement.
• Pramipexole immediate-release medication is used for treating the symptoms of restless legs syndrome. This condition may cause discomfort in the legs and a desire to move legs when sitting down or lying.

What Are the Forms & Strengths of Pramipexole?

Pramipexole comes as an immediate and extended-release oral tablet with the following strengths:

Immediate-Release Tablet

• 0.125 mg
• 0.25 mg
• 0.5 mg
• 0.75 mg
• 1 mg, and 
• 1.5 mg  

Extended-Release Tablet

• 0.375 mg
• 0.75 mg
• 1.5 mg
• 2.25 mg
• 3 mg
• 3.75 mg, and 
• 4.5 mg

What Are the Recommended Dosage of Pramipexole?

The dosage recommendations for Pramipexole depend on several factors, including the type and severity of your medical condition and the form of medication you take. Generally, medical professionals prescribe a starting dose and gradually adjust the drug doses as needed. It is important to note that the dosage recommendations below are only for the average dose. So, if you have been prescribed a different dose, do not change it without consulting your medical practitioner. 

Dosage for Parkinson’s Disease

For Adults (IR Tablets)

• On Week 1: Take 0.125 mg dose thrice daily
• On Week 2: Take 0.25 mg tablet thrice daily
• On Week 3: Take 0.5 mg tablet three times a day
• On Week 4: Take 0.75 mg dose thrice daily
• On Week 5: Take 1 mg dose three times a day
• On Week 6: Take 1.25 mg tablet three times daily
• On Week 7: Take 1.5 mg tablet thrice a day.

For Adults (ER Tablets)

• Starting Dose: Administer 0.375 mg oral tablet once daily
• Dosage Increase: Your doctor will gradually increase the dosage every 5 to 7 days
• Maximum Dose: 4.5 mg once daily

For Pediatric Patients (Under 18 Years)

• The drug has not shown safety and effectiveness in this age group. Do not use this medication in children below 18 years of age.

Dosage for Moderate to Severe Primary RLS (Restless Legs Syndrome)

For Adults (IR Tablets)

• Starting Dose: Administer 0.125 mg oral tablet once daily, usually in the evening. Take the medication preferably 2 to 3 hours before bed.
• Dosage Increase: Your doctor will gradually increase the dosage every 4 to 7 days if needed.
• Maximum Dose: 0.5 mg once daily in the evening

For Pediatric Patients (Under 18 Years)

• The drug has not shown safety and effectiveness in this age group. Do not use this medication in children below 18 years of age.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Pramipexole?

• Before proceeding to the administration steps, read the patient information leaflet or medication guide thoroughly provided by your doctor or pharmacist. Doing so will provide you with detailed information. If you have any questions, you can ask a medical professional.
• Follow the dosage recommendations exactly as your doctor prescribes.
• Take the medication by mouth with or without food as your practitioner instructed. However, taking the tablets with food may lessen your nausea. 
• Swallow the tablets as a whole with a glass of water unless directed otherwise.
• Do not break, chew, split, or crush the tablets. Doing so may release the drug at once, increasing the risk of side effects.
• If you are unable to swallow the medication as a whole, talk to your medical practitioner. They will suggest some alternate options.
• Take each medicine at the same time regularly to get the most benefit from it.
• Do not discontinue the treatment suddenly without consulting your doctor. Doing so may worsen the condition and cause withdrawal symptoms like anxiety, confusion, muscle stiffness, and fever. 
• If you stop this medication temporarily due to certain reasons, you need to start the treatment with a low dose. Your doctor will then gradually increase the dosage if needed. 
• Do not stop taking the medication even if you feel well. Complete the course that has been prescribed to you.
• It may take a few weeks to notice the medication’s effects. If your condition does not improve within the mentioned time or gets intense, visit a medical practitioner. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Pramipexole Work?

Pramipexole works by mimicking the action of dopamine, a natural substance in the brain that is crucial for controlling movement. As a dopamine agonist, it stimulates dopamine receptors, helping to alleviate symptoms of Parkinson’s disease and Restless Legs Syndrome (RLS). By activating these receptors, Pramipexole improves motor function and reduces discomfort. This mechanism helps enhance movement control, making it easier for patients to perform daily activities & reducing the involuntary movements and sensations associated with these conditions.

Important Safety Information for Using Pramipexole

What Are the Side Effects of Pramipexole?

Common Side Effects of Pramipexole: This medication may lead to various side effects. These temporary reactions usually last for a few days to weeks. However, if they get intense or persist for a long time, get immediate medical assistance. Common side effects of Pramipexole may include:

• Weakness
• Dizziness and drowsiness
• Confusion
• Nausea
• Not feeling hungry
• Diarrhea
• Constipation
• Unusual body movements
• Strange thoughts/dreams
• Dry mouth
• Swelling in the legs or arms
• Frequent urination
• Trouble sleeping

Serious Side Effects of Pramipexole: Other than common side effects, Pramipexole can cause certain adverse reactions that can be life-threatening. If you are experiencing any signs that may seem concerning, reach out to a medical professional. Serious side effects of Pramipexole may include:

• Psychotic-like behavior. Its symptoms may include:
  • Unusual behavior, including agitation, aggression, and delirium
  • Confusion
  • Extreme aggression
• Rhabdomyolysis (muscle breakdown). Signs may include:
  • Muscle weakness
  • Soreness or stiffness
  • Dark-colored urine
• Hallucinations. Symptoms are:
  • Seeing things that do not exist
  • Hearing things that do not exist
• Postural deformities 
• Vision problems

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Pramipexole?

Pramipexole can cause severe side effects in certain patients, or it may not be an ideal treatment option for specific populations due to their medical conditions. So, if you are using Pramipexole, you should remain cautious as it has several warnings, which are as follows:

• Falling Asleep Suddenly: This medication may make you fall asleep suddenly while doing activities. This can happen without any warnings. This situation can become dangerous while driving or operating heavy machines. So, talk to a medical professional about driving or anything requiring alertness.
• Dizziness and Fainting: Pramipexole can cause nausea, sweating, dizziness, and fainting when standing up immediately from a sitting or lying position. These issues are more common at the initial stage of the treatment. To avoid this risk, move slowly while you stand up. 
• Impulsive or Compulsive Behavior: This drug can increase your urge to gamble or engage in sexual behaviors. If you are noticing such things, talk to your doctor.
• Hallucinations: Pramipexole may increase the risk of hallucinating in patients or may change behaviors. This can result in confusion, aggression, or agitation. Therefore, consult a medical professional before starting your treatment with this medication.
• Postural Deformity: This medication may lead to changes in your posture. These can include antecollis (forward neck leaning), camptocormia (forward bending at the waist), and pleurothotonus (sideways leaning at the waist). These changes often occur after beginning the medication or increasing the dose and may appear several months into treatment. If you experience any of these symptoms, contact your doctor immediately. They may adjust your dosage or discontinue your medication.

What Are the FDA Boxed Warning for Pramipexole?

Boxed warnings, also called black-boxed warnings, are among the most stringent guidelines issued by the FDA. These warnings alert doctors and patients about the harmful effects of a particular drug, which can be life-threatening if overlooked. Pramipexole does not have any boxed warnings, meaning it is safe to use. However, its safety is based on the precautions you take. Therefore, if you are taking this drug, follow the instructions provided by your medical practitioner. If you have any concerns or noticed any unusual symptoms, it’s best to consult with an expert.

What Are the Pramipexole Precautions?

When considering treatment with Pramipexole, patients should discuss every risk and benefit with their medical practitioner. Here are some of the precautions that you can take before using Pramipexole:

• Before taking this medication, tell your medical practitioner about your allergies or if you are allergic to the medication’s ingredients. The product may contain certain inactive components that cause severe allergic reactions.
• Before considering treatment with Pramipexole, inform your doctor about your or your family’s history, especially of: 
  • Heart problems
  • Low blood pressure
  • Mood disorders
  • Kidney issues
  • Sleep disorder
• Pramipexole can make you dizzy, and consuming alcohol and marijuana can increase the risk of dizziness. So, avoid alcoholic beverages while taking this medication.
• If you are undergoing surgery or any medical procedure, tell your surgeon or medical practitioner about the products you use. This includes all prescription drugs, over-the-counter medications, and herbal products.
• Older adults should take medication under the guidance of a healthcare professional, as this drug can increase the risk of dizziness and hallucinations.
• If you are pregnant or planning to have a baby, avoid using Pramipexole unless it is clearly needed, as the medication may harm the unborn baby. Consult an expert practitioner and discuss every risk and benefit associated with it.
• Breastfeeding is not recommended during Pramipexole treatment as the drug may enter the breast milk & harm the nursing baby. It can also affect the mother’s milk production. So, lactating women are advised to talk to a healthcare practitioner before making any decision.
• During your treatment with Pramipexole, visit your nearby clinic frequently. Doctors will closely monitor your progress report to prevent any unusual symptoms.   
• If you are experiencing dark urine, fever, muscle pain, stiffness, cramps, or tiredness, talk to a medical professional. These may be signs of muscle disease called rhabdomyolysis.

What Are the Contraindications of Pramipexole?

This medication is contraindicated in patients with a known hypersensitivity to Pramipexole or any of its formulation’s ingredients.

What If You Missed a Dose of Pramipexole?

Generally, it is advisable not to miss any doses of Pramipexole, but if someone forgets, they can:

• Skip the missed dose and continue following their regular dosing schedule. However, if it is an extended-release tablet and the time for a new dose is less than 12 hours, take the missed dose as soon as possible. Once the skipped dose is taken, continue with the regular dosing schedule.
• If the missed extended-release dose is not taken within 12 hours, skip it and take the next dose at the regular time.
• Remember not to take double doses of your prescribed medication just for the sake of making up for the missed dose. This may cause adverse side effects.
• Use medication apps or set reminders on your phone to avoid skipping any doses.
• Take each dose at the same time every day to get the most benefit out of it.
• If you are still unsure about the missed doses, talk to an expert physician. They will guide you and suggest alternate options.  

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Pramipexole?

While patients are educated enough to know the complications of overdose, there are times when they mistakenly take an excessive amount of Pramipexole tablets. In such cases, patients are advised not to panic and instead look for unusual signs like:

• Nasal congestion
• Nausea
• Vomiting
• Dry mouth
• Headache
• Flushing
• Coughing
• Excessive sweating
• Hallucinations
• Claustrophobia
• Fatigue
• Energy loss
• Palpitations
• Unusual movements in shoulders, face, and hips
• Nightmare

If you are experiencing such overdose symptoms, visit the nearest clinic or get medical assistance immediately by calling 911.  

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store a Pramipexole?

• Store the medication at room temperature of 15°C and 30°C.
• Keep the tablets protected from light and moisture, and avoid placing them under direct sunlight.
• Store your medication somewhere safe in a locked container so that it is away from the reach and sight of children.
• Avoid keeping your medicines in damp or moist places like the bathroom or near the sink.
• Do not flush the medication down the toilet.
• Avoid freezing the medication.
• Discard the product when not in use.
• Do not use a medication if its expiration date has passed. The expiration date is the last day of the month mentioned on the back of the prescription label or carton.
• You should dispose of the medications in such a way that children and animals cannot consume them, as it may cause accidental overdose and death if someone else consumes them.
• The best way to eliminate unwanted medications is to give them in the medicine take-back program.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Pramipexole?

Drug interactions occur when one or more medications are taken simultaneously. These interactions can either raise the risk of developing side effects in certain patients or affect the functioning of one of the drugs. Either way, it results in adverse reactions. Therefore, patients need to be aware of the drugs that may interact with their Pramipexole medication. Below are some of the drugs that can interact with Pramipexole:

• Amisulpride
• Amoxapine
• Brexanolone
• Brexpiprazole
• Chlorpromazine
• Clozapine
• Droperidol
• Esketamine
• Fluphenazine
• Haloperidol
• Iloperidone
• Loxapine
• Lumateperone
• Lurasidone
• Mesoridazine
• Methdilazine
• Olanzapine
• Paliperidone
• Perphenazine
• Pimozide
• Quetiapine
• Risperidone
• Sodium Oxybate
• Thiethylperazine
• Thioridazine
• Thiothixene
• Ziprasidone

What Are the Other Pramipexole Interactions?

Besides drugs, the presence of certain medical problems may impact the functioning and effects of Pramipexole. So, if you have any of the following conditions during your treatment with this medication, talk to a medical professional. These other interactions are:

• Dyskinesia 
• Hallucinations 
• Hypotension
• Postural hypotension 
• Kidney disease
• Sleep disorders 
• Neuroleptic malignant syndrome 

[Note: This isn’t a complete list, and there could be other drugs that interact with Pramipexole. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Pramipexole Alternatives?

People usually take alternative drugs for many reasons. In some cases, the prescribed medication may not be an ideal option for them due to their medical conditions. On the other hand, they may not achieve the results they are aiming for. Therefore, you should talk to a medical professional before you start a particular treatment or if you want to change your medication. They may help you decide which medication is best suited for you. Some of the alternatives to Pramipexole are as follows:

• Valbenazine
• Austedo
• Sinemet
• Ropinirole
• Gabapentin
• Clonazepam
• Neupro
• Tramadol
• Amantadine
• Azilect
• Rytary
• Rasagiline

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Pramipexole Cost & Coupons

It is important to note that Pramipexole’s cost is not the same everywhere. The actual price of these tablets depends on several factors, including your insurance plan, location, and the pharmacies you use. Pramipexole, with its therapeutic qualities, can be expensive for certain patients. Here, insurance coverage plays a significant role. You can buy your medication at affordable rates with an insurance coverage plan. However, not all drugs/medications are covered under the insurance plan. If you are residing in America and searching for affordable pharmacies to manage your medication’s cost, reach out to Polar Bear Meds. Here you can buy Pramipexole online from Canada in the USA at discounted rates. Moreover, first-time buyers can use the Pramipexole coupon code WELCOMEPB10 to receive a 10% discount on their first order.

Frequently Asked Questions

Does Pramipexole start working immediately?

Pramipexole may not start working immediately. It usually takes a few weeks for patients to notice significant improvements in their symptoms. The onset of action may vary depending on individual response and the condition being treated. Consistent use as prescribed by your doctor is essential for optimal results. Patience and adherence to the treatment plan are crucial.

What happens if you suddenly stop taking Pramipexole?

Suddenly stopping Pramipexole can lead to withdrawal symptoms, including fever, confusion, and muscle stiffness. It may also worsen Parkinson’s disease or Restless Legs Syndrome symptoms. Always consult your medical professional before discontinuing the medication, as they may need to reduce the dose to prevent adverse effects gradually. Sudden cessation can cause significant health complications.

Can Pramipexole affect my heart?

Pramipexole may have effects on the heart, such as causing low blood pressure (orthostatic hypotension) or irregular heartbeats. Patients with pre-existing heart conditions should use it cautiously and under close medical supervision. Regular monitoring of heart function is recommended to ensure safety while taking this medication. Discuss any heart-related concerns with your medical provider.

Is Pramipexole an addictive medication?

Pramipexole is not considered an addictive medication. However, it may lead to compulsive behaviors in some individuals, such as gambling or excessive spending. Patients should inform their doctor of any unusual urges or behaviors. Proper medical guidance helps manage these potential side effects effectively. Awareness and communication with your doctor are key.

Can I take Pramipexole for the long term?

Pramipexole can be taken long-term if prescribed by your doctor. Long-term use is often necessary for managing chronic conditions like Parkinson’s disease & Restless Legs Syndrome. Regular follow-up appointments with your healthcare practitioner ensure the medication remains effective and any side effects are promptly addressed. Following the prescribed dosage schedule is essential for ongoing symptom management.

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