Spironolactone and Hydrochlorothiazide 

Spironolactone / Hydrochlorothiazide 

Spironolactone/Hydrochlorothiazide is an FDA-approved combination medication used to treat hypertension and edema in individuals with congestive heart failure, liver cirrhosis, or a kidney condition known as nephrotic syndrome. It contains two medications as its active ingredients: spironolactone and hydrochlorothiazide. The prescription medication is available in the form of tablets with two different strengths: 25 mg Spironolactone/25 mg Hydrochlorothiazide & 50 mg Spironolactone/50 mg Hydrochlorothiazide to be taken orally with or without food. Consult a licensed healthcare provider for personalized advice and guidance for the safe and efficient use of the medication.  

Product Overview

Spironolactone/Hydrochlorothiazide is an FDA-approved combination medication containing two active ingredients: Spironolactone, a potassium-sparing diuretic, and Hydrochlorothiazide, a thiazide diuretic. This combination primarily treats hypertension (high blood pressure) and edema by helping the body eliminate excess salt and water while retaining potassium, which reduces blood pressure & fluid buildup. 

The prescription medication is available in tablet form with two strengths: 25 mg Spironolactone/25 mg Hydrochlorothiazide & 50 mg Spironolactone/50 mg Hydrochlorothiazide. It should be taken orally or by mouth, either as a single dose or in divided doses, with or without food. The medication dosage is based on the patient’s condition and response to treatment. Following the doctor’s prescription is essential, as the medication’s effectiveness relies on consistent usage. Children and adults can take this medication under a doctor’s supervision.

Common side effects of Spironolactone / Hydrochlorothiazide may include dizziness, leg cramps, and electrolyte imbalances. Patients should avoid driving a vehicle or using heavy machinery if they have dizziness or drowsiness unless they can do it safely. It is crucial to monitor for severe side effects, such as allergic reactions or high potassium levels, and seek medical attention if required. You should take a missed dose as soon as remembered unless it is almost time to take the next scheduled dose. Store the medication in a cool, dark & dry place, away from children and pets, and follow proper disposal guidelines for unused tablets. Always consult an expert medical provider for personalized advice.

What Are the Uses of Spironolactone / Hydrochlorothiazide?

It is used to treat

• High blood pressure (hypertension)
• Edema 

What Are the Forms & Strengths of Spironolactone / Hydrochlorothiazide?

It is available in the form of a tablet, which comes with the following strengths:

• 25 mg Spironolactone and 25 mg Hydrochlorothiazide 
• 50 mg Spironolactone and 50 mg Hydrochlorothiazide 

What Are the Recommended Dosage of Spironolactone / Hydrochlorothiazide?

The medication dosage for each patient varies based on age, medical condition & response to treatment. For safe and efficient use of the medication, you should follow the instructions given by your doctor and the directions for use given in the patient information leaflet & medication guide provided by your pharmacist or healthcare provider. 

The amount of medication you take depends on its strength and form. It also depends on the number of doses you take each day, the gap between each dose, and the duration of the medication course. 

For High Blood Pressure

• Adults: Initially, you should take 50-100 mg each of Spironolactone and Hydrochlorothiazide daily, given as a single dose or divided doses. Your doctor may make dosage adjustments as required. 
• Children: Your doctor will determine your usage and dosage. 

For Edema

• Adults: The initial daily recommended dose is 100 mg of each Spironolactone and Hydrochlorothiazide, given as either a single dose or divided into various doses. Your doctor may make dosage adjustments as needed. 
• Children: Your doctor will determine your usage and dosage. 

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Spironolactone / Hydrochlorothiazide? 

• Before using Spironolactone HCTZ, you should carefully read and follow the instructions for use given in the patient information leaflet & medication guide provided by your pharmacist or healthcare provider. If you have any queries or concerns or if you do not understand any part of the information leaflet, you should consult an expert medical practitioner. 
• You should take this medication orally by mouth, exactly as your doctor prescribes, or follow the directions mentioned on the prescription label. Do not take it more or less than prescribed, in large quantities, or more frequently than recommended. 
• The medication dosage is based on the amount of medicine you take and the strength of the tablet. It may also be influenced by the number of prescribed doses in a day, the gap between each dose, and the duration of the treatment. 
• If your doctor has prescribed you a different dose than the one mentioned above, you should follow your doctor’s instructions and do not change it unless instructed otherwise.  
• Swallow the Spironolactone HCTZ tablet as a whole with a glass of water. Do not crush, break, or chew it. 
• Spironolactone / Hydrochlorothiazide can be taken with or without food. However, if you experience an upset stomach, it can be taken with food or milk. 
• This medication is to be used in combination with a treatment plan consisting of weight control and dietary changes. Before making any major dietary adjustments, you can consult your dietician and ask your doctor which of the abovementioned changes is most important for you. 
• You should continue taking your medication even if you feel well. Do not discontinue taking this medication without consulting a licensed healthcare professional, as it can cause unwelcome side effects. 
• This medication will not help you cure your condition but manage it. You should continue to use it as recommended if you want to lower your blood pressure. 
• Usually, most patients with hypertension do not experience any symptoms and may feel normal, so you should take it daily. If you and your doctor determine that this medication is safe for you to use long-term, you may have to take it for the rest of your life. 
• To get the most benefit from your medication, you should maintain consistency in dosage and try to take it around the same time every day. 
• Do not share this medication with other people, even if they have the same symptoms as you, as it can cause unwanted side effects. 
• If your condition does not get better or if it worsens, tell your doctor. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Spironolactone / Hydrochlorothiazide Work?

This product contains two ingredients: Spironolactone and Hydrochlorothiazide. Both medications are diuretics (water pills), which help your body get rid of extra salt and water, which further relaxes the blood vessels helping blood flow easily. This may also increase the urine amount when you initially start using the medication. This medication is also effective in the treatment of low blood potassium levels and blocks the activity of aldosterone, a natural substance present in the body that can cause edema. Your doctor may first prescribe that you start taking Spironolactone and Hydrochlorothiazide separately, and if it is suitable for you, then switch over to this combination medication, including both medications as ingredients.

Important Safety Information for Using Spironolactone / Hydrochlorothiazide

What Are the Side Effects of Spironolactone/Hydrochlorothiazide?

Common Side Effects of Spironolactone & Hydrochlorothiazide: Similar to other medications, a combination of Spironolactone and Hydrochlorothiazide may cause side effects in some people using it. These side effects are not usually severe and do not require medical attention. They disappear within a few days or weeks as your body starts to adjust to the medication. It is noteworthy to mention that not everyone using this medication experiences these side effects. The common side effects of Spironolactone and Hydrochlorothiazide are as follows: 

• Leg cramps
• Drowsiness 
• Weakness 
• Dizziness
• Lack of energy 
• Feeling like you may pass out 
• Electrolyte imbalance 
• Nausea
• Vomiting 
• Severe pain in the upper side of the abdomen spreading to your back 

Mild Side Effects of Spironolactone / Hydrochlorothiazide: This medication can cause certain mild side effects in some people using it. Usually, most mild side effects do not require any medical attention, so you should report any new or worsening symptoms to your doctor right away and inform them about any persisting or worrying side effects caused by Spironolactone HCTZ. 

• Cramp
• Dizziness
• Allergy
• Diarrhea
• Arthralgia
• Indigestion
• Breast pain or swelling
• Anorexia
• Easy bruising
• Vomiting
• Blurred vision
• Confusion
• Heart arrhythmia
• Headache
• Dehydration
• Difficulty maintaining or achieving an erection
• Drowsiness
• Irregular Menstrual Periods
• Medication
• Tiredness
• Yellowing eyes or skin
• Blood in stools
• Dark urine

Serious Side Effects of Spironolactone / Hydrochlorothiazide: In rare cases, Spironolactone HCTZ may cause severe side effects in some people using it. These side effects require prompt medical assistance and can be life-threatening if not treated promptly. You should know that the following list does not cover all possible side effects caused by this medication, and there may be others, too. You should call your doctor or 911 immediately if you notice any of the following side effects:

• Allergic reaction. Its symptoms may include hives, skin rash, fever, trouble breathing, and swelling of the mouth/lips/tongue/throat. 
• Fluid and electrolyte imbalance. Its symptoms may include extreme thirst, extreme fatigue and weakness, rapid heart rate, dizziness, or mouth dryness. 
• Extremely high potassium levels in your body. Its symptoms may include an inability to move your arms and legs, muscle weakness, extreme fatigue, a slow heart rate, or tingling or numbness in your arms and hands. 
• Gynecomastia 
• Severe skin reactions. Symptoms may include blistering or peeling easily, skin discoloration, and loosening of the skin, particularly inside the mouth. 
• Cardiovascular issues. Symptoms may include chest pain or tightness, severe dizziness or fainting, and rapid or irregular heartbeat. 
• Kidney or urinary issues. Its symptoms may include changes in the frequency or amount of urine, blood in the urine, or painful or difficult urination.
• Liver issues. Its symptoms may include yellowing of the skin/eyes, dark urine, or severe abdominal pain. 

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Spironolactone / Hydrochlorothiazide? 

There are certain warnings that you should take into consideration while using this medication. 

• The safety & efficacy of this medication have not been established in the pediatric population, so you should consult an expert medical practitioner before using Spironolactone / Hydrochlorothiazide for children.
• You should not use Spironolactone / Hydrochlorothiazide if you have an allergy to any of the excipients of the product. Also, inform your medical team about all other allergies you may have.   
• Spironolactone / Hydrochlorothiazide may interact with other medications. Before using this medication, you should tell your doctor about all the medications you are using or plan to use, including all prescription, non-prescription, and over-the-counter drugs and herbal or vitamin supplements.  
• If you experience signs and symptoms of an allergy, including rash, hives, or swelling in your face, mouth, hand, or feet, you should discontinue using this medication and call your doctor at once. 
• You should monitor your blood pressure on a regular basis, especially during the initial period of treatment with this medication, and share the reports with your doctor. 
• This combination medication is not recommended during pregnancy due to the greater risk of fetal abnormalities with thiazide diuretics. If you are pregnant, suspect a pregnancy, or plan to become pregnant while using this medication, immediately call your doctor. 
• If your doctor has recommended you to take a low-sodium diet or daily exercise program, you should continue to follow it and avoid potassium-containing salt substitutes while receiving treatment with Spironolactone / Hydrochlorothiazide. You may also be required to limit your consumption of foods containing high levels of potassium. For more information, you should consult an expert medical practitioner. 

What Are the FDA Boxed Warning for Spironolactone / Hydrochlorothiazide?

A boxed warning has been issued by the FDA for Spironolactone / Hydrochlorothiazide due to certain risks associated with its use. The key points of the boxed warning are as follows:

• Spironolactone has been shown to be producing or tending to produce tumors in a study conducted in rats, which means that it has the potential to cause tumors when used for an extended period of time. 
• Spironolactone and Hydrochlorothiazide can cause significant electrolyte imbalances, which may lead to severe health issues.  
• The combination medication containing Spironolactone / Hydrochlorothiazide can lead to severely high potassium levels in the body, especially when taken with other potassium-sparing diuretics, angiotensin II receptor antagonists, ACE inhibitors, NSAIDs, or potassium supplements. 
• The medication should only be used for conditions that have been specifically indicated. And it should be used under strict medical supervision to avoid unnecessary risks. 

What Are the Spironolactone / Hydrochlorothiazide Precautions?

When deciding to start using a medication, you should consult a licensed healthcare professional, discuss with them in detail, and weigh the risks associated with the use of the medication and its benefits. For Spironolactone / Hydrochlorothiazide, you should consider the following. 

• Before using this medication, you should tell your doctor if you have an allergy to Spironolactone or Hydrochlorothiazide or if you have any other allergies to dyes, drugs, herbs, or vitamin supplements. This medication may contain certain inactive ingredients or other issues. You should talk to your pharmacist or doctor regarding the complete list of the ingredients present in the medication. 
• Before using Spironolactone / Hydrochlorothiazide, you should share your complete medical and family history with your doctor, especially if you have the following conditions:
  • Untreated salt/mineral imbalance 
  • Kidney disease
  • Liver condition
  • Dehydration
  • Gout 
  • Lupus
  • High levels of fat in the blood
  • Decreased adrenal gland function 
  • Skin disease
• If you plan to have a surgery, including a dental procedure, you should tell your dentist, doctor, or surgeon about all the medications you are using, including Spironolactone / Hydrochlorothiazide. Also tell them about all the prescription, non-prescription, over-the-counter drugs, herbal, or vitamin supplements you may be taking. 
• Spironolactone / Hydrochlorothiazide may make you feel dizzy or drowsy. Alcohol consumption or using marijuana may increase this effect. You should not drive a vehicle, use heavy machinery, or engage in tasks that require mental alertness or clear vision unless you can do it safely. 
• If you experience severe sweating,  vomiting, or diarrhea, it can make you feel lightheaded. Call your doctor immediately if you have severe vomiting or diarhea. You should increase your fluid intake while receiving treatment with Spironolactone / Hydrochlorothiazide to prevent dehydration, unless instructed otherwise by your doctor. 
• Spironolactone / Hydrochlorothiazide can increase your sensitivity to the sun, which can further increase your risk of skin cancer, especially when it is taken for a long time. To prevent this, you should limit your time under the sun, avoid sunlamps and tanning booths, and wear protective clothing & sunscreen when you are under the sun. Call your doctor if you have redness, skin blisters, new moles, or skin lesions. 
• If you have diabetes mellitus type 1 or 2, this medication can affect your blood glucose levels. You should check your blood glucose levels on a regular basis and share the reports with your doctor. Inform your doctor if you experience symptoms of hyperglycemia, such as increased thirst or urination. Your doctor may suggest you make certain dietary changes or make adjustments to your medication or exercise program. 
• Spironolactone / Hydrochlorothiazide can affect the levels of potassium in your bloodstream. You should consult an expert medical practitioner before using potassium supplements or salt substitutes that have potassium. 
• Geriatric patients are at a greater risk of certain side effects caused by this medication, such as its effects on potassium, lightheadedness, or dizziness. The feeling of lightheadedness or dizziness can increase the risk of unintentional falling. 
• Spironolactone / Hydrochlorothiazide can pass into breast milk but is unlikely to cause harm to the breastfeeding infant. However, you should consult your medical team before breastfeeding a baby while receiving treatment with this medication.   

What Are the Contraindications of Spironolactone / Hydrochlorothiazide?

Spironolactone / Hydrochlorothiazide is contraindicated for patients who have:

• Anuria
• Severe renal impairment
• Addison’s disease
• Hyponatremia
• Hyperkalemia
• Pregnancy
• Breastfeeding

What If You Missed a Dose of Spironolactone / Hydrochlorothiazide?

• If you have missed a dose of Spironolactone / Hydrochlorothiazide, you should take it as soon as you remember. 
• However, if it is almost time to take your next dose of Spironolactone HCTZ, you may omit the missed dose and continue taking your medication according to your regular dosing schedule. 
• You should not take double or extra doses of the same medication to compensate for the missed dose, as it can lead to undesirable side effects. 
• To further prevent missing doses, you should set a reminder on your phone. Medication reminders work best for this purpose. 

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Spironolactone / Hydrochlorothiazide?

You should not take Spironolactone / Hydrochlorothiazide more than recommended as it can cause severe side effects. Symptoms of Spironolactone / Hydrochlorothiazide overdose may include disorientation, drowsiness, mood or mental changes, hallucination, lethargy, lightheadedness, or rashes. If you suspect an overdose, you should seek immediate medical assistance. You can call 911, a poison control helpline, or an expert medical professional. You can also head to the nearest emergency room. 

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store a Spironolactone / Hydrochlorothiazide?

Following the proper storage guidelines is essential for the safe and efficient use of the medication.

• You should keep Spironolactone / Hydrochlorothiazide in its original container or blister pack to protect it from direct sunlight, excess heat, and moisture. Do not keep it in the bathroom, under the sink, or in places with high humidity as moisture can cause damage to certain medications. 
• You should keep all medications, including Spironolactone / Hydrochlorothiazide, in a tightly sealed container in a secure place away from the reach and sight of children & pets to avoid accidental consumption of the drug. 
• Do not allow the medication to freeze or be exposed to extreme temperatures. 
• Do not keep medications that are no longer needed or have passed their expiration date, which is the last day of the month mentioned on the back of the blister pack or carton. You should dispose of them safely.
• You should refrain from pouring them in the water, flushing them down the toilet, or throwing them into the household garbage bin unless instructed otherwise by your healthcare provider. 
• You should discard unwanted and outdated medications in such a way that prevents children, animals, and others from consuming them. 
• The best way to eliminate unwanted medications is to give them in the medicine take-back program. 
• For more information on how to properly dispose of unwanted medications, you should consult your local waste disposal company, pharmacist, or healthcare provider. 

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Spironolactone / Hydrochlorothiazide?

Certain medications may interact with Spironolactone / Hydrochlorothiazide and reduce its effectiveness or cause undesirable side effects. Before using this medicine, you should tell your doctor or pharmacist about all the medications you are using or plan to use alongside Spironolactone / Hydrochlorothiazide, including all prescription, non-prescription medications, over-the-counter drugs, and herbal or vitamin supplements. This information will help you and your healthcare provider identify and prevent drug interactions. Some of the potential drug interactions of this medication are as follows:

• Abiraterone Acetate
• Acarbose
• Aceclofenac
• Acemetacin
• Acetyldigoxin
• Alacepril
• Albiglutide
• Albuterol
• Alogliptin
• Amphetamine
• Amtolmetin Guacil
• Arginine
• Arsenic Trioxide
• Aspirin
• Benazepril
• Benzphetamine
• Bromfenac
• Bromocriptine
• Bufexamac
• Buprenorphine
• Canagliflozin
• Captopril
• Cefepime
• Celecoxib
• Chlorpropamide
• Choline Salicylate
• Cilazapril
• Clonixin
• Codeine
• Cosyntropin
• Cyclosporine
• Dabigatran Etexilate
• Dapagliflozin
• Delapril
• Deslanoside
• Desmopressin
• Dexibuprofen
• Dexketoprofen
• Dextroamphetamine
• Diclofenac
• Diflunisal
• Digitalis
• Digitoxin
• Digoxin
• Dihydrocodeine
• Dipyrone
• Dofetilide
• Droperidol
• Droxicam
• Dulaglutide
• Empagliflozin
• Enalaprilat
• Enalapril Maleate
• Eplerenone
• Etodolac
• Etofenamate
• Etoricoxib
• Exenatide
• Felbinac
• Fenoprofen
• Fentanyl
• Fepradinol
• Feprazone
• Flecainide
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Formoterol
• Fosinopril
• Glimepiride
• Glipizide
• Glyburide
• Hydromorphone
• Ibuprofen
• Imidapril
• Indomethacin
• Insulin
• Insulin Aspart, Recombinant
• Insulin Bovine
• Insulin Degludec
• Insulin Detemir
• Insulin Glulisine
• Ketanserin
• Ketoprofen
• Ketorolac
• Levomethadyl
• Linagliptin
• Liraglutide
• Lisdexamfetamine
• Lisinopril
• Lithium
• Lixisenatide
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Mavorixafor
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Meperidine
• Methadone
• Methamphetamine
• Methotrexate
• Metildigoxin
• Miglitol
• Mitotane
• Moexipril
• Morniflumate
• Morphine
• Morphine Sulfate Liposome
• Nabumetone
• Naproxen
• Nateglinide
• Nepafenac
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Oliceridine
• Ouabain
• Oxaprozin
• Oxymorphone
• Oxyphenbutazone
• Parecoxib
• Pentopril
• Perindopril
• Phenylbutazone
• Piketoprofen
• Pioglitazone
• Piroxicam
• Porfimer
• Potassium
• Potassium Citrate
• Potassium Phosphate
• Pramlintide
• Pranoprofen
• Proglumetacin
• Propyphenazone
• Proquazone
• Proscillaridin
• Quinapril
• Ramipril
• Repaglinide
• Repotrectinib
• Rofecoxib
• Rosiglitazone
• Salicylic Acid
• Salsalate
• Saxagliptin
• Sitagliptin
• Sodium Salicylate
• Sotalol
• Sparsentan
• Spirapril
• Sufentanil
• Sulindac
• Tacrolimus
• Tapentadol
• Temocapril
• Tenofovir Alafenamide
• Tenoxicam
• Tiaprofenic Acid
• Tolazamide
• Tolbutamide
• Tolfenamic Acid
• Tolmetin
• Topiramate
• Tramadol
• Trandolapril
• Triamterene
• Trimethoprim
• Valdecoxib
• Vildagliptin
• Vonoprazan
• Zofenopril

What Are the Other Spironolactone / Hydrochlorothiazide Interactions?

Apart from medications, certain food items, beverages, herbal remedies, and vitamin supplements may interact with Spironolactone / Hydrochlorothiazide and affect its effectiveness. Consuming alcohol or tobacco intake while receiving treatment with certain medications can also cause certain interactions to occur. This medication also has certain disease interactions that you should consider to prevent and manage potential drug interactions. 

• Adrenal problems 
• Anuria 
• Hypercalcemia 
• Hyperkalemia 
• Electrolyte imbalance 
• Severe kidney disease
• Severe liver disease
• History of sulfa drug allergy 
• Asthma
• Diabetes 
• Fluid imbalance 
• Glaucoma
• Gout 
• High levels of cholesterol in the blood 
• Myopia 
• Systemic lupus erythematosus 
• Sympathectomy 

[Note: This isn’t a complete list, and there could be other drugs that interact with Spironolactone / Hydrochlorothiazide. Tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Spironolactone / Hydrochlorothiazide Alternatives?

While Spironolactone / Hydrochlorothiazide is an effective medication used to treat hypertension (high blood pressure), it may not be suitable for everyone or may fail to provide desired results to the patient. For this reason, people are looking for alternatives to Spironolactone / Hydrochlorothiazide. There are many popular substitutes for Spironolactone HCTZ available on the market. If you plan to switch from your existing medication, you should get in touch with your doctor and according to your age, needs, and medical condition, they will help you determine the medication that will work the best for you. Some of the popular Spironolactone HCTZ alternatives are as follows: 

• Zestril
• Diovan (valsartan) 
• Norvasc (amlodipine)
• Lasix (furosemide)
• Aldactone
• Altace
• Vasotec

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Spironolactone / Hydrochlorothiazide Cost & Coupons

The cost of Spironolactone/Hydrochlorothiazide can vary based on factors including health insurance coverage & the purpose for which it is prescribed. Unfortunately, many health insurance plans in the U.S. do not cover this medication when used for weight loss, leading to significant out-of-pocket expenses for patients. To help manage these costs, some individuals opt to purchase Spironolactone/Hydrochlorothiazide from Canadian pharmacies, where prices are often lower. Services like Polar Bear Meds offer this medication at reduced rates, and new customers can get a 10% discount on their first order using the coupon code WELCOMEPB10.

Frequently Asked Questions

When is the best time to take Spironolactone and Hydrochlorothiazide?

The best time to take Spironolactone and Hydrochlorothiazide is in the morning or early afternoon. Taking these diuretics earlier in the day helps avoid nighttime urination, which can cause sleep disturbances. You should follow your healthcare provider’s instructions regarding timing to maximize the effectiveness of the medication while minimizing potential side effects, such as frequent urination and electrolyte imbalances.

Why are the diuretics Hydrochlorothiazide and Spironolactone often given together?

Hydrochlorothiazide and Spironolactone are often prescribed together because their effects complement each other. Hydrochlorothiazide is a thiazide diuretic that helps eliminate excess sodium and water but can lead to potassium loss. Spironolactone is a potassium-sparing diuretic that helps retain potassium. When used together, these medications effectively manage fluid balance and blood pressure while minimizing the risk of potassium deficiency.

Why are Hydrochlorothiazide and Spironolactone given together?

Hydrochlorothiazide and Spironolactone are given together to enhance their diuretic and antihypertensive effects. Hydrochlorothiazide helps reduce fluid retention and lower blood pressure, while Spironolactone prevents potassium loss, which is a common side effect of many diuretics. This combination provides a balanced approach to treating conditions like hypertension and edema by addressing both fluid retention and electrolyte balance.

What is the combination of Spironolactone and Hydrochlorothiazide?

Spironolactone and Hydrochlorothiazide are dual-acting diuretics used primarily to treat hypertension and edema. Spironolactone is a potassium-sparing diuretic, whereas Hydrochlorothiazide is a thiazide diuretic. Together, they work by eliminating excess fluid from the body while maintaining potassium levels, making the combination effective for patients who need diuretic therapy but are at risk of potassium depletion.

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