Trazodone 

Trazodone Hydrochloride 

Trazodone is an FDA-approved antidepressant that belongs to a drug class called serotonin modulators. The prescription medication is used to treat depression and related disorders. It mainly contains trazodone as its main ingredient, which functions by modulating the brain’s serotonin levels. It is available in the form of a tablet that comes in strengths of 50mg, 100mg, 150mg, and 300mg, to be taken orally once or twice daily, with or without food. You should take Trazodone exactly as prescribed by your doctor. You can seek guidance from a licensed medical provider if you have any queries regarding the medication usage or dosage. 

Product Overview

Trazodone Hydrochloride is a medication primarily containing trazodone, which is used to treat major depressive disorder. It functions by modulating the brain’s serotonin levels, though the exact mechanism is not fully known. This adjustment helps to improve mood, appetite, and energy levels, aiding in the recovery from depression.

Available in various strengths, Trazodone Hydrochloride is typically prescribed in dosages that reflect the severity of the condition being treated. To reduce stomach upset, it should be taken exactly as directed by a healthcare provider, usually once or twice daily following a meal or snack. It is suitable for adults and should be taken regularly to achieve the maximum benefit. The drug’s action involves restoring the balance of serotonin in the brain, which helps to enhance mood and alleviate the symptoms of depression.

Patients may experience side effects, including drowsiness, dizziness, or dry mouth. It’s crucial to consult a doctor if any of these persist or worsen. Important precautions include avoiding alcohol and alerting the prescriber to any history of bipolar disorder or eye problems. If a dose is missed, take it as soon as remembered unless it’s near the time of the next dose. In case of Trazodone overdose, seek immediate medical attention. Trazodone Hydrochloride should be stored at room temperature, away from light and moisture. Always follow the recommendation of your healthcare provider regarding use & potential interactions.

What Are the Uses of Trazodone Hydrochloride?

It is used to treat:

• Depression 

What Are the Forms & Strengths of Trazodone Hydrochloride?

It is available in the form of a tablet that comes in the following strengths:

• 50 mg 
• 100 mg
• 150 mg 
• 300 mg  

What Are the Recommended Dosage of Trazodone Hydrochloride?

For Depression 

For Adults

• Initial dose: 150 mg taken orally every day with or without food, in divided doses. 
• Maintenance dose: Your doctor may increase your dose up to 300 mg daily. 
• Maximum dose: 400 mg daily

For Elderly Patients

• Initial dose: 75-100 mg daily to minimize the risk of side effects.
• Dosage adjustments are made more cautiously in this population. 

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Trazodone Hydrochloride? 

• Before taking this medication, you should carefully read and follow the instructions for use given in the medication guide or patient information leaflet shared by your healthcare provider or pharmacist. If you have any queries or concerns or if you do not understand any part of this leaflet, you should ask your doctor. 
• Take Trazodone Hydrochloride exactly as prescribed by your doctor. Your doctor may occasionally change your medication dose. Do not take more or less of it, in large quantities, or more frequently than prescribed, as it may lead to unwanted side effects. 
• If your medication dose is 300 mg or less daily, your doctor will most likely tell you to take it as a single dose at night. Since Trazodone may make you feel sleepy, using it at night time may help if you are having difficulty sleeping. 
• You may take it after a meal or snack to decrease the chance of an upset stomach. 
• It may take up to two weeks before your symptoms get better.
• You should continue to take this medication even if you feel well. You should not stop taking it abruptly, as it may cause unwanted side effects such as vomiting, sweating, confusion, dizziness, tingling, or numbness. If you plan to discontinue taking this medication, you should tell your doctor. They will help you gradually taper off the medication to lessen the chances of withdrawal symptoms.  
• Tell your doctor if your condition does not get better or if it worsens. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Trazodone Hydrochloride Work?

Trazodone hydrochloride is an antidepressant that belongs to the class of serotonin antagonists & reuptake inhibitors or SARIs. It works primarily by affecting neurotransmitters in the brain, particularly serotonin. Trazodone inhibits the reuptake of serotonin, allowing more of this neurotransmitter to remain available in the synaptic cleft. This action is believed to help regulate mood and alleviate depressive symptoms. Additionally, Trazodone acts as an antagonist at certain serotonin receptors, which contributes to its sedative effects. It also has some action on other neurotransmitters like norepinephrine and histamine, which may contribute to its overall antidepressant and sleep-promoting effects.

Important Safety Information for Using Trazodone Hydrochloride

What Are the Side Effects of Trazodone Hydrochloride?

Common Side Effects of Trazodone Hydrochloride: Like many medications, Trazodone Hydrochloride may cause a range of common side effects that are generally not severe and often disappear as your body adjusts to the medication. A significant number of patients experience these effects and usually do not require medical attention unless they persist or become bothersome. Common side effects include:

• Drowsiness
• Dizziness
• Dry mouth 
• Blurred vision 
• Constipation 
• Headache 
• Nausea 
• Vomiting 
• Changes in weight or appetite 
• Sweating 

Mild Side Effects of Trazodone Hydrochloride: In addition to the common side effects, some patients may experience mild side effects that are less frequent but still not typically cause for significant concern. These effects may be temporary and often resolve on their own. However, if they persist or worsen, it’s best recommended to consult a healthcare provider. Mild side effects can include:

• Confusion 
• Weakness
• Muscle pain
• Skin rash 
• Itching
• Nervousness
• Changes in sexual desire or ability
• Ringing sensation in the ears.

Serious Side Effects of Trazodone Hydrochloride: Trazodone Hydrochloride may potentially cause serious side effects that require immediate medical attention. These effects are generally rare but can be significant if they occur. It’s crucial to be aware of these potentially serious side effects and seek medical help promptly if they are experienced. Serious side effects may include:

• Priapism (prolonged, painful erection lasting more than four years) 
• Cardiac conditions. Its symptoms may include irregular or fast heartbeat, chest pain, shortness of breath, severe dizziness, and fainting 
• Severe infections
• Hematological disorders. Its symptoms may include unusual bruising, bleeding gums, blood in stool or urine, or nosebleeds.
• Liver dysfunction. Its symptoms may include dark urine, vomiting, stomach pain, persistent nausea, yellowing of the skin or the eyes, or dark urine.
• Seizures. Its symptoms may include loss of consciousness, convulsions, and uncontrollable jerking movements. 
• Serotonin syndrome. Its symptoms may include hallucinations, agitation, dizziness, rapid heart rate, flushing, muscle tremor or rigidity, vomiting/nausea, or diarrhea.
• Severe allergic reactions, including anaphylaxis. Its symptoms may include swelling of the face/throat/mouth/tongue, difficulty breathing, itching, hives, or severe rash. 
• Low sodium levels. Its symptoms may include confusion, weakness, headache, difficulty concentrating, or memory problems.
• Angle-closure glaucoma. Its symptoms may include vision changes, severe eye pain, redness in the eye, and swelling around the eye.
• QT prolongation. Its symptoms may include seizures, fainting, or irregular heartbeat.
• Suicidal ideation. Its symptoms may include thoughts of self-harm, unusual changes in mood or behavior, or worsening depression.  

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Trazodone Hydrochloride? 

• You should not take this medication if you have an allergy to Trazodone or any of its ingredients. Your pharmacist or healthcare provider can provide a complete list of the medication’s ingredients. 
• You should not take this medication while you are using certain other medications. To know about potential drug interactions of this medication, tell your doctor about all the medicines you are taking or plan to take, including all prescription, non-prescription, over-the-counter drugs, and herbal or vitamin supplements. 
• Do not take this medication if you have used an MAO inhibitor in the last 14 days, as it may cause a severe drug interaction. MAO inhibitors include linezolid, isocarboxazid, phenelzine, tranylcypromine, and more.
• Some young people may experience suicidal thoughts when starting an antidepressant. Your doctor will monitor your progress through check-ups on a regular basis while you are on Trazodone. Family members or caregivers should also be attentive to any changes in your mood or symptoms.
• Notify your doctor immediately if you experience any new or exacerbating symptoms, such as changes in mood or behavior, anxiety, panic attacks, difficulty sleeping, or if you feel irritable, impulsive, agitated, hostile, aggressive, restless, overly energetic (mentally or physically), more depressed, or have thoughts of suicide or self-harm.
• Do not give this medication to anyone under 18 years old without a doctor’s advice, as Trazodone is not approved for use in children.

What Are the FDA Boxed Warning for Trazodone Hydrochloride?

FDA has issued a boxed warning for Trazodone Hydrochloride due to the risk of suicidal thoughts or actions, particularly in adolescents and young adults. While this side effect is rare, it is crucial to be aware of signs & symptoms such as changes in mood or thoughts, suicidal behavior or ideation, or worsening depression. 

What Are the Trazodone Hydrochloride Precautions?

• Before using Trazodone, tell your healthcare provider about all your health conditions and any medications, vitamins, minerals, herbal products, or other supplements you are taking. This information helps determine whether Trazodone is suitable for you. 
• Before using Trazodone Hydrochloride, share your complete medical and family history with your doctor, especially if you have the following conditions:
  • Bipolar disorder or mania
  • Bleeding disorders
  • Heart issues, including any family history of QT prolongation (a rare, serious heart rhythm problem)
  • Liver or kidney problems
  • Low sodium levels
  • Glaucoma
  • History of heart attack
  • Peyronie’s disease
  • Sickle cell anemia, leukemia, multiple myeloma, or other serious medical conditions
• You should not take Trazodone Hydrochloride unless it has been prescribed to you by a licensed healthcare professional. Take it exactly as your doctor prescribed.
• Do not share this medication with others, even if they have the same condition as you, as it can cause harm to them.
• Keep this medication in a safe place, away from the sight and reach of children and pets.
• To prevent the chance of an upset stomach, you should take this medication shortly after a meal or light snack. 
• You should not crush or chew the Trazodone tablet. If necessary, your doctor may suggest breaking it in half along the score line. 
• Trazodone may impact your alertness and coordination. Avoid driving, operating heavy machinery, or indulging in tasks that require these abilities until you understand how the medication affects you. If you feel drowsy or fatigued after taking Trazodone, inform your healthcare provider. They might adjust your dose or recommend taking it at a different time.
• Do not discontinue Trazodone without consulting your healthcare provider. Stopping it abruptly can lead to serious side effects, including anxiety, agitation, and sleep disturbances.
• It is unknown how Trazodone affects pregnancy or an unborn baby. Let your healthcare provider know if you are pregnant, suspect a pregnancy, or planning to become pregnant. They will advise you on whether you should take Trazodone during this time. 
• Trazodone may pass into breast milk. Tell your healthcare provider if you are breastfeeding or planning to breastfeed, and they will guide you on whether it’s safe to use Trazodone while nursing.

What Are the Contraindications of Trazodone Hydrochloride?

Trazodone Hydrochloride is contraindicated for use in patients who:

• Have an allergy to Trazodone or any of the ingredients listed in the medication. 
• Are being treated with methylene blue injection
• Are less than 18 years of age
• Are concurrently using MAOIs or within 14 days of stopping MAOIs. 

What If You Missed a Dose of Trazodone Hydrochloride?

• If you have missed a dose of Trazodone Hydrochloride, you should take it as soon as you remember. 
• However, if it is almost time for your next dose, you may omit the missed dose and continue taking your medication according to the regular dosing schedule. 
• Do not simultaneously take double or extra doses of the same medication to compensate for the missed dose, as it can cause undesirable side effects.  

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Trazodone Hydrochloride?

If you suspect an overdose of Trazodone Hydrochloride, you should seek immediate medical attention. You can call your doctor, 911, or poison control helpline. You may also head to the nearest emergency room.  

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

How to Store a Trazodone Hydrochloride?

• Keep Trazodone Hydrochloride in its original container to protect it from direct sunlight, excess heat, and moisture. Store at room temperature in a dark and dry place. 
• Keep all medications, including Trazodone Hydrochloride, in a safe place, away from the sight and reach of children and pets. 
• Do not keep medications that are outdated or no longer needed. Discard them safely. 
• Do not pour unwanted medication down the drain, flush it down the toilet, or throw it into the household garbage bin. 
• You should dispose of unwanted medications in such a way that prevents children, animals and others from consuming them. 
• The best way to eliminate unwanted medications is to give them in the medicine-take-back program. 
• To learn more about the proper ways to dispose of unwanted medications, you should consult your healthcare provider, pharmacist, or local waste disposal company. 

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Trazodone Hydrochloride?

Certain medications may interact with Trazodone and affect how it may work, potentially leading to severe side effects or reduced therapeutic benefits. Before using this medication, it is crucial to tell your healthcare provider, pharmacist or doctor about all the medications you are using or plan to use. This includes all prescription, non-prescription, over-the-counter drugs, and herbal or vitamin supplements. This information helps in identifying and managing potential drug interactions of Trazodone. Here are some important drug interactions to consider while taking Trazodone Hydrochloride:

• Bepridil
• Bromopride
• Cisapride
• Dronedarone
• Fluconazole
• Isocarboxazid
• Ketoconazole
• Ketazolam
• Ketobemidone
• Ketoprofen
• Ketorolac
• Levoketoconazole
• Linezolid
• Mesoridazine
• Methylene Blue
• Moclobemide
• Nelfinavir
• Nialamide
• Octreotide
• Ofloxacin
• Olanzapine
• Oliceridine
• Omaveloxolone
• Ondansetron
• Opipramol
• Phenelzine
• Pimozide
• Piperaquine
• Posaconazole
• Procarbazine
• Rasagiline
• Safinamide
• Saquinavir
• Selegiline
• Sparfloxacin
• Terfenadine
• Thioridazine
• Tranylcypromine
• Valdecoxib
• Vandetanib
• Vardenafil
• Vemurafenib
• Venlafaxine
• Vilanterol
• Vilazodone
• Vinflunine
• Voclosporin
• Vorapaxar
• Voriconazole
• Vorinostat
• Vortioxetine
• Ziprasidone 

What Are the Other Trazodone Hydrochloride Interactions?

Other than medications, certain herbs, supplements, food items, and beverages may interact with Trazodone Hydrochloride and reduce its effectiveness or cause undesirable side effects. Your doctor may advise you to make certain dietary changes to prevent such interactions. It is important to note that this list is not exhaustive, and other interactions may exist. Inform your doctor about all supplements and significant dietary habits to prevent drug interactions with Trazodone. 

• Grapefruit juice
• St. John’s Wort

[Note: This isn’t a complete list, and there could be other drugs that interact with Trazodone Hydrochloride. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Trazodone Hydrochloride Alternatives?

Trazodone Hydrochloride is an effective medication used to treat depression and related disorders. While it is suitable for most patients, it may cause unwanted side effects or does not provide desirable results for some individuals who use it. Taking into account factors such as the patient’s symptoms, medical history, potential side effects, and personal preferences, your doctor can prescribe you a substitute for Trazodone. Here are some alternatives to Trazodone Hydrochloride. 

• Mirtazapine (mirtazapine)
• Doxepin hydrochloride
• Amitriptyline
• Paroxetine
• Bupropion (bupropion hydrochloride XL) 

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Trazodone Hydrochloride Cost & Coupons

Trazodone Hydrochloride is a medication that many find essential, yet it often isn’t covered by health insurance, leading to significant out-of-pocket expenses. Alternative purchasing options, such as sourcing from Canadian pharmacies, are available to help manage these costs. One reputable option is Polar Bear Meds, which offers Trazodone Hydrochloride at more affordable rates compared to typical U.S. prices. Customers looking to further reduce expenses can utilize the coupon code WELCOMEPB10 at Polar Bear Meds, granting a 10% discount on their first purchase. This approach can make a critical difference for those needing regular access to Trazodone Hydrochloride without the burden of high costs.

Frequently Asked Questions

What is the biggest side effect of Trazodone?

The most significant side effect of Trazodone can be priapism, a rare but serious condition involving a painful, prolonged erection. This needs prompt medical attention to prevent permanent damage to the penis. Other common side effects include drowsiness and dizziness, which vary in intensity among individuals.

Is Trazodone safe to take daily?

Trazodone is generally safe for daily use when prescribed by a healthcare provider and taken according to the prescribed dosage. Regular monitoring by a medic is crucial to adjust dosages & manage any potential side effects or interactions with other medications.

Is Trazodone an SSRI or SNRI?

Trazodone is neither an SSRI nor an SNRI. It is categorized as a serotonin antagonist & reuptake inhibitor. Trazodone works by preventing the reuptake of serotonin in the brain and by blocking certain serotonin receptors, which helps to balance the levels of serotonin and alleviate depressive symptoms.

What is the FDA guidance for Trazodone?

The FDA advises that Trazodone should only be used as prescribed by a healthcare professional. It includes warnings about potential severe side effects such as priapism, QT interval prolongation, and the risk of suicidal thoughts & behaviors in young adults, especially when starting the medicine or adjusting the dose. Regular follow-ups and caution when used in combination with other central nervous system depressants are recommended.

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