Motilium

Domperidone

Domperidone 10 mg tablet, also known by its brand name, Motilium, is a prokinetic medication. It offers effective relief from nausea, vomiting, and symptoms of gastroparesis, like slow stomach emptying. In addition, it facilitates easier bowel movement through the digestive tract by blocking certain brain messengers that cause vomiting and enhancing stomach and intestinal contractions. Recommended for use before meals to improve absorption, its dosage varies by patient age and condition, under strict medical guidance. While beneficial, it requires caution in patients with heart conditions or on certain medications due to risks of QT prolongation. Always consult a healthcare provider for personalized advice and dosing.

Domperidone Overview

Domperidone is a prokinetic medication primarily used to relieve symptoms of nausea, vomiting, and gastroparesis. It works by enhancing the movement of the stomach and intestines, allowing food to move more easily through the stomach and preventing the discomfort associated with slow-moving digestion and reflux diseases.

The standard dosage for adults involves a 10 mg tablet taken three to four times daily before meals and possibly before bedtime, with a maximum daily limit of 80 mg. For children, doses are adjusted based on weight, emphasizing careful administration under medical supervision. Domperidone is also available in various forms, including oral tablets, suspensions, and suppositories, allowing for flexibility in administration based on patient needs and preferences.

It is critical to adhere to prescribed doses and consult healthcare professionals regarding the duration of use, especially since the medication can cause side effects like dizziness, irregular heartbeats, and hormonal changes. Special caution is advised for patients with existing heart conditions or electrolyte imbalances due to the risk of QT prolongation. Always discuss potential drug interactions and ensure that Domperidone is suitable for you, particularly in the presence of other medications.

What Are the Uses of Domperidone?

Domperidone 20 mg tablet is used in the following ways:

• Treatment of Gastroesophageal Reflux Disease (GERD)
• Relieving nausea and vomiting

What Are the Forms & Strengths of Domperidone?

Dosage

Motilium is a medication that should be taken exactly as directed by your doctor. Make sure to read and fully understand the information provided by your doctor or pharmacist. This medication comes in the form of tablets that should be taken orally. It is important to take the tablet 30 minutes before a meal. Make sure to store this medication safely and away from heat or moisture. 

What Are the Recommended Domperidone Doses for Different Patients?

Domperidone comes in 3 forms & the recommended dosages can vary based on the form of the medication and patient characteristics such as age and overall health. Here are the dosing recommendations for Domperidone in its various forms:

Tablets: Take one Domperidone 10mg tablet up to three times daily, ideally before meals. Limiting intake to three tablets (30 mg) daily is advised, though your doctor might suggest up to four tablets (40 mg) in certain situations.

Oral Suspension: The standard dose is 10 ml taken up to three times daily, preferably before meals. The daily amount should be at most 30 ml.

Suppositories: Commonly, use one 30 mg suppository twice a day. Do not exceed two suppositories daily.

Special Considerations

Elderly Patients: They may require a lower dose, depending on kidney function and overall health.

Patients with Renal Impairment: Dose adjustment may be necessary, and intervals between doses may be extended.

[Note: Always consult a healthcare professional for the appropriate dose of Domperidone and never exceed the recommended dose.]

How to Use Domperidone?

Domperidone is a medication used primarily to treat nausea and vomiting and sometimes issues like gastroparesis. Here are some general guidelines on how to use it:

• Always take this medicine exactly as your doctor or pharmacist tells you to. You should check with them if you are not sure.
• Your doctor will decide how long you will require to take this medicine. Gastric symptoms can be easily resolved within 3-4 days of taking Domperidone. Do not take this medication for more than 7 days without talking to your doctor.

Oral Forms of Domperidone 

• Take this medication by mouth.
• For best results, take oral Domperidone 15 mg tablet 15 to 30 minutes before meals. Taking it after meals may slow down its absorption.
• Swallow the Domperidone 20 mg tablet whole with water. Do not crush or chew them.
• Orally disintegrating tablets (also known as orodispersible tablets) can dissolve in your mouth and don’t need to be taken with water.
• If using the oral suspension form, measure the dose with the plastic measuring cup provided.
• If using the oral drops, measure the dose with the dropper provided.

Suppositories Containing Domperidone

• Wash your hands before starting.
• Moisten the suppository before insertion.
• Insert the suppository into the rectum as far as it can go.
• Tense your muscles to keep the suppository in place.
• Eating or drinking does not impact the effectiveness of Domperidone suppositories.

[Note: Consult your qualified medical professional to get personalized dosage forms before taking Domperidone.]

How Does Domperidone Work?

Motilium (Domperidone) blocks certain chemical messengers in the brain responsible for causing nausea and vomiting. By doing so, it effectively reduces these symptoms. Additionally, it enhances the contractions in the stomach, facilitating a smoother and more efficient food movement through the digestive tract. This is particularly beneficial in conditions like gastroparesis, where slow food movement can cause discomfort and exacerbate GERD symptoms. Through these actions, Domperidone improves overall digestive health and comfort.

Important Safety Information

What Are the Side Effects of Domperidone?

When you buy Domperidone 10mg to relieve vomiting, nausea, and symptoms of gastroparesis, you can also consider the common side effects associated with this medication. This includes:

• Irregular menstrual periods: Domperidone can disrupt the normal hormonal balance in women, leading to irregularities in the menstrual cycle. This can manifest as changes in the frequency, duration, or flow of menstrual periods.
• Secretion of breast milk in women: Known as galactorrhea, this condition involves the production of breast milk in women who are not breastfeeding. Domperidone increases prolactin levels, which can stimulate milk production.
• Low sex drive in men: By altering hormone levels, particularly by increasing prolactin, Domperidone can lead to a decreased libido in men.
• Breast tenderness/enlargement in men: This effect, known as gynecomastia, involves the swelling of breast tissues in men due to hormonal imbalances caused by elevated levels of prolactin.
• Rash or itchy skin: Domperidone can cause allergic reactions, which may manifest as rashes, hives, or generalized itching.
• Dry mouth or thirst: The medication may affect salivary secretion, leading to a feeling of dryness in the mouth or an increased sensation of thirst.
• Mouth ulcers: Some individuals may develop ulcers in the mouth, which can be painful and uncomfortable, as a side effect of Domperidone.
• Itchy eyes: This can occur either as part of an allergic reaction or as an isolated symptom, causing discomfort and a persistent urge to rub the eyes.
• Drowsiness: Domperidone can cause a sedative effect, leading to sleepiness or drowsiness, which might affect daily activities.
• Headache: This common side effect can range from mild to severe and may occur frequently while on the medication.
• Trouble sleeping: Despite its potential to cause drowsiness, Domperidone can also lead to insomnia or difficulty in maintaining sleep.
• Food regurgitation: The medication can affect digestive motility and lead to the sensation of food coming back up into the esophagus after eating.
• Constipation: Domperidone can slow gastrointestinal motility, leading to reduced bowel movements and constipation.

Tell your doctor if any of the symptoms still persist or become worse. In some cases, domperidone 15 mg tablet can also cause mild side effects in some users. They are not usually serious and go away in a couple of days or weeks as your body starts to adjust to the medication. Still, you should report any new or worsening symptoms to your doctor immediately. Some of the mild side effects of Domperidone include: 

• Mild abdominal cramps: Some patients using this medication might experience occasional stomach discomfort or cramping. These symptoms are usually mild & do not require medical attention.
• Dizziness: Some patients may feel lightheaded or off-balance. This side effect is usually temporary and may get better as the body adjusts to the medication. You should not engage in hazardous tasks such as driving a car or using machinery unless you can do it safely. 
• Reduced appetite: The medication might slightly decrease hunger or interest in food. This side effect is temporary. However, if you notice a persistent lack of appetite or significant weight loss, talk to a medical professional.
• Flushing: Some patients may experience temporary warming or redness of the skin, specifically on the neck and face, while using Domperidone. This is usually harmless and disappears on its own within a few days or weeks. 
• Mild anxiety: Some individuals may experience slight feelings of unease or worry. If these feelings persist or intensify, it’s important to discuss them with your doctor. 
• Mild allergic reactions: Some patients may experience a mild allergic reaction to Domperidone or any of its excipients. Its symptoms include mild itching, a skin rash all over the body, swelling under the skin, hives, mild wheezing, or trouble breathing. 

Domperidone has the potential to lead to severe side effects. It is crucial to discontinue the use of Domperidone immediately and seek medical attention from a doctor or visit a hospital without delay if you experience any of the following symptoms:

• Swelling of the Lower Extremities: Noticeable increase in the size of your feet, ankles, or hands, which could indicate fluid retention.
• Increased Urination: An unusual increase in the frequency or amount of urine compared to what is normal for you.
• Heart Rhythm Changes: Experiencing a heartbeat that feels unusually fast or irregular, which can be a sign of heart-related issues.
• Allergic Reaction to Motilium: Symptoms may include difficulty breathing, shortness of breath, or swelling of the face. These reactions can be serious and require immediate medical intervention.

[Note: If you experience any of the side effects mentioned above, it is important to consult with your doctor about them.] 

What Are the Domperidone Warnings?

If you have a heart condition like QT prolongation, heart failure, or low levels of magnesium or potassium, talk to your doctor about how Domperidone 15 mg tablet might affect you. It’s important to discuss how your condition could influence Domperidone’s dosing and effectiveness and if you need special monitoring.

Domperidone can increase the risk of sudden cardiac death and ventricular arrhythmias. If you have an existing heart condition or electrolyte imbalance, you have an increased risk of heart-related issues. If you plan to use this medication for the long term, your doctor will monitor you closely and ask you to undergo ECG tests on a regular basis. 

This is crucial if you’re on medications that could alter your heart’s electrical activity or increase Domperidone levels in your blood. Some drugs, such as sotalol, quinidine, and others, can raise the risk of QT prolongation when taken with Domperidone. Avoid using them together if possible, especially if you’re at higher risk for heart rhythm issues. Consult with your doctor if you are:

• are a woman
• older than 65 years of age
• family history of sudden cardiac death
• history of heart disease or abnormal heart rhythms
• slow heart rate
• have congenital prolongation of the QT interval
• have diabetes
• have had stroke events
• low potassium, magnesium, or calcium levels
• nutritional deficiencies

What Are the Domperidone Precautions?

While it can be an effective treatment, there are several precautions and considerations to be aware of when you buy Domperidone 10mg:

• It may cause dizziness and sleepiness. Avoid driving or activities requiring mental alertness until you know how it affects you.
• Avoid alcohol while taking Domperidone, as it can increase drowsiness.
• Dry mouth is a possible side effect. To alleviate this, rinse your mouth frequently, maintain good oral hygiene, drink more water, and use sugar-free candy.
• Notify your doctor if you experience watery diarrhea, fever, or persistent stomach pain.
• Do not use this medication for more than 7 days without consulting your doctor.
• To decrease the chance of adverse side effects, use Domperidone 15 mg at the lowest effective dose for the shortest duration possible. 
• Domperidone is not recommended for children under 12 years old or weighing less than 35 kg, as its safety and effectiveness have not been established.
• Use this medication with caution in patients over 65 years old due to the risk of side effects. Dosage adjustments may be necessary.
• Pregnant women should use this medication only if the benefits outweigh the risks. Consult your doctor before use.
• Breastfeeding mothers should avoid this medication due to potential adverse effects on the infant. Discuss the benefits and risks with your doctor before taking it.

What Are Domperidone Contraindications?

Domperidone (Pharmacy Health) is contraindicated in the following situations:

• Hypersensitivity to Domperidone or any other extender.
• Prolactin‐releasing pituitary tumor(prolactinoma).
• If given to children under 2 years of age.
• Taking Domperidone with strong CYP3A4 inhibitors can increase its levels in the body, potentially leading to prolonged QT intervals. Examples of such inhibitors include certain antifungal medications (like itraconazole, voriconazole, posaconazole), some antibiotics (such as clarithromycin, telithromycin), and certain protease inhibitors (including ritonavir, saquinavir, telaprevir).

• Avoid using Domperidone with other medicines that can extend the QTc interval.
• Do not use Domperidone when there is a need to stimulate gastrointestinal movement.

What Happens If You Miss a Dose of Domperidone?

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not double doses or take extra doses to compensate for your missed dose. If you frequently miss taking your medication, you should talk to a licensed healthcare practitioner to learn about ways in which you can maintain consistency in dosage. You can also set a reminder on your phone to prevent missing doses. Medication reminders are best for helping you remember to take your medication dosage on time. 

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much Domperidone?

Overdosing on Domperidone can be hazardous. Exceeding your prescribed dosage may result in a rapid or irregular heartbeat. Symptoms of Domperidone overdosage include altered consciousness, agitation, convulsions, disorientation, drowsiness, and extrapyramidal reactions. If you experience any of these symptoms, seek prompt medical attention. You can call your medical team or 911. You may also head to the nearest emergency room. 

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How Do You Store Domperidone?

Domperidone should be stored according to the instructions provided by the manufacturer, which are typically found on the medication package or included in the leaflet. Generally, here are some common guidelines for storing Domperidone:

• Store Domperidone at room temperature between 68-77°F (20-25°C) or as directed.
• Protect from light.
• Avoid refrigerating or freezing Domperidone suppositories. Do not store in temperatures above 77°F (25°C).
• Store all medications, including Domperidone, in a location that is not visible or accessible to children and pets to avoid accidental consumption.
• Domperidone tablet has a shelf life of thirty-six months. Do not use it past its expiration date. 
• Keep checking the expiration date of the medications you are using at regular intervals. The expiration date is the last day of the month, given on the back of your prescription label and medication packaging. Do not use the medication if it has passed its expiration date or if it is no longer needed. Dispose of it safely. 
• You should discard unwanted or outdated medicines in such a way that does not allow children, pets, and other people to consume them. 

[Note: The information shared here is for informational purposes. For better understanding, always consult with a medical professional]

What Are the Domperidone Interactions?

Before starting to use Domperidone, tell your doctor about all the medications you are currently using or plan to use alongside this medicine. Tell them about all the prescription medications, non-prescription, over-the-counter drugs, and vitamin or herbal supplements. This information helps you & your doctor identify and prevent the potential drug interactions of Domperidone. Do not take Domperidone if you are taking medicine to treat:

• Fungal Infections: Medications used to treat fungal infections can alter the metabolism of Domperidone, potentially leading to increased side effects.
• Heart Problems or High Blood Pressure: Certain drugs for heart conditions or hypertension may interact with Domperidone, increasing the risk of heart-related side effects.
• Bacterial Infections: Antibiotics might interfere with how Domperidone is metabolized or absorbed in your body.
• Cancer: Some treatments for cancer could potentially conflict with the action of Domperidone.
• Psychosis: Medications for treating psychosis may also interact, affecting how each drug works or is processed by the body.
• Gastrointestinal Disorders: Other drugs used to manage gastrointestinal issues might have adverse interactions with Domperidone.
• Depression: Antidepressants can affect the metabolism of Domperidone, potentially leading to an increased risk of side effects.
• Allergy: Allergy medications, especially those that affect the serotonin system, might interact with Domperidone.
• AIDS/HIV: Drugs used in the treatment of AIDS/HIV can affect how Domperidone is processed in the body.
• Malaria: Antimalarial drugs may also have interactions with Domperidone.

What Are the Other Domperidone Interactions?

Domperidone can interact with a variety of other medications and substances, such as herbs, supplements, food items, and beverages, which can further increase your risk of unwanted side effects or decrease the effect of the drug. To prevent this, your doctor may advise you to make certain dietary changes while receiving treatment with Domperidone. Here are some other interactions:

• Alcohol: It is advisable to avoid alcohol while undergoing treatment with Domperidone, as it may heighten the likelihood of experiencing severe side effects like dizziness, drowsiness, impaired focus, gastrointestinal bleeding, weakness, and fatigue.
• Herbs & Supplements: The safety of using complementary medicines and herbal remedies in conjunction with Domperidone has not been well-established. Therefore, caution is recommended when considering such additions to your regimen. Consult with a healthcare provider before combining Domperidone with any other treatments.

[Note: Tell your healthcare provider about all the medicines you take better to understand the other types of interactions of Domperidone.]

What Are the Domperidone Alternatives?

If you’re looking for alternatives to Domperidone, several options can be considered depending on the specific symptoms or conditions being treated. While there are many effective substitutes to Domperidone available in the market, you should not change your medication or start a new one without consulting your medical provider or doctor, as it can cause unwanted side effects. Here are some common alternatives:

• Maxeran (metoclopramide), also known as Reglan or Metonia
• Benzamycin (erythromycin)
• Propulsid (cisapride)
• Resotran (prucalopride)
• Zofran (ondansetron)
• Phenergan (promethazine)
• relamorelin
• Constella (linaclotide)
• Cesamet (nabilone)

[Note: This list of medicines for gastroparesis is just for general knowledge. It shouldn’t replace any guidance you’ve gotten from your doctor.]

Domperidone Cost & Coupons

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Frequently Asked Questions

Who cannot take domperidone?

To ensure that Domperidone is safe for you to use, tell your doctor if you have heart conditions such as prolonged QT intervals or other cardiac rhythm disorders, hepatic issues, prolactinomas, gastrointestinal bleeding, allergy to Domperidone or any of its excipients, children aged less than 12 years and pregnant or breastfeeding.

Is Domperidone Available in the USA?

Currently, Domperidone is unavailable in the USA. You can ask your healthcare provider for a prescription of Domperidone if you want to take it, which can be submitted to Polar Bear Meds. You can order this medication or the brand name Motilium through our Canadian online pharmacy. If you buy Domperidone USA online through Polar Bear Meds, you can save a lot and have your prescription delivered straight to your door.

What happens when you stop taking Domperidone?

When you suddenly stop taking Domperidone, it can cause withdrawal symptoms that include psychosis, intense anxiety, insomnia, and tachycardia. Breastfeeding websites have reported instances where women have experienced disturbing symptoms such as depression, anxiety, and even psychosis after suddenly stopping the use of the medicine. Patients need to consult with their doctor before making any decisions regarding the discontinuation of this medication.

Can Domperidone help with bloating?

Motilium is effective in addressing symptoms like stomach bloating, excessive fullness, nausea, and belching, often experienced alongside discomfort and heartburn post-meals. As a member of the dopamine antagonist drug class, Domperidone enhances gastrointestinal movement, aiding in symptom relief.

What impact does Domperidone have on the heart?

This medication is associated with a condition known as QT prolongation, which affects the heart’s rhythm. It can lead to a serious and occasionally deadly fast or irregular heartbeat, along with other serious symptoms like severe dizziness and fainting, all of which urgently need medical care.

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